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Can You Drink Alcohol While Taking Adderall?

Jessica Men
Written by:
Jessica Men
PharmD
Dr. Henry Bradford
Medical Reviewer:
Dr. Henry Bradford
MD
The medications listed on this website are provided for informational purposes only.
Their inclusion does not guarantee they will be prescribed to any individual, as treatment decisions are ultimately at the discretion of healthcare providers. Healthcare providers may prescribe other medications, including non-stimulant options, or recommend non-pharmacological treatment based on the patient’s unique health circumstances and needs. Read more

Adderall has a boxed warning[1] , the most serious type of warning from the Food and Drug Administration (FDA). Adderall’s active ingredient (amphetamines) has a risk of misuse (abuse) which can lead to dependence, serious heart conditions, and even sudden death. Adderall is also a controlled substance, indicating its high potential for misuse or dependence. Specific federal and state laws limit the amount of this medication that can be prescribed or dispensed within a certain period of time.

Highlights

  • Do not combine alcohol and Adderall.
  • Mixing depressants like alcohol and stimulants like Adderall can cause a spectrum of harmful side effects.
  • Mixing Adderall and alcohol can mask the effects of either substance, making you unaware of how much you are drinking.
  • If you or someone you know may have taken Adderall and alcohol together, be sure to monitor symptoms and seek appropriate medical attention if needed.

What Is Adderall?

Adderall (dextroamphetamine-amphetamine) is a central nervous system stimulant medication that is used to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy. It functions by increasing the amounts of dopamine and norepinephrine in the body to improve alertness and energy levels. 

Medications like Adderall are controlled Schedule II substances in the US due to their high potential for misuse and addiction. Because of their possible euphoric effects[2] , they are commonly abused, which can lead to addiction and serious health risks.

Receive a personalized treatment plan for ADHD and get all your questions answered online.

How Do Adderall and Alcohol Affect the Body?

Adderall, a central nervous system stimulant, and alcohol[3] , a central nervous system depressant, affect the body in opposing ways.

Effect

Adderall (Stimulant)

Alcohol (Depressant)

Primary Action

Speeds up central nervous system

Slows down central nervous system

Energy Levels

Increases alertness and energy

Causes sedation and fatigue

Mood and Behavior

Increases focus and confidence. May increase anxiety

Can lower inhibitions, impair judgment

Heart Rate & Blood Pressure

Raises heart rate and blood pressure

Initially lowers, then may raise heart rate

Appetite

Suppresses appetite

May increase appetite or cause nausea

Bodily Processes

Reduces impulsive movements

May compromise motor skills

Combining Adderall and alcohol won’t simply balance the other out. In fact, mixing the two can dangerously mask the effects of either substance, making you feel like you’re not being affected. This can lead to increased consumption, increased risk of harmful side effects[4] , and accidental overdose.

What Are the Dangers and Risks of Drinking on Adderall?

Short‑Term Health Effects

There are various short-term side effects that become amplified when Adderall and alcohol are combined, such as:

  • Anxiety
  • Impaired ability to operate a vehicle
  • Elevated blood pressure and heart rate
  • Elevated body temperature
  • Nausea/vomiting
  • Blackouts
  • Aggressive behavior
  • Increased likelihood of risk-taking behaviors[5] and harm to others
  • Alcohol poisoning (caused by overdrinking due to the masking of effects)
"Stimulants can mask the sedative effects of alcohol, making people feel less intoxicated than they really are. This may lead to drinking more, raising blood alcohol concentration, and the risk of alcohol poisoning. At the same time, stimulants elevate heart rate and blood pressure, so the combination can place dangerous strain on the cardiovascular system."
Dr. Henry Bradford, MD
Medical provider at MEDvidi

Serious Medical Complications

More serious effects can also occur, including sudden death. Other potential serious complications include:

  • Shortness of breath
  • Loss of coordination
  • Chest pain
  • Heart attack
  • Dizziness
  • Seizures
  • Mental health effects such as mania, hallucinations, or delusion
  • Coma

Seek medical help if you experience any of the above.

Long‑Term Risks & Polysubstance Use

Repeatedly mixing Adderall and alcohol comes with long-term risks and may indicate a potential polysubstance use disorder. One indicator of a substance use disorder is the development of dependence, which occurs when a person’s body has adapted to the substance so much that they feel like they cannot function normally without it. 

The consistent use of alcohol with Adderall can also lead to complications and serious damage[4] to the brain, heart, and other organs; and addiction.

Why Do Some People Mix These Substances?

Despite the dangers of drinking alcohol while taking Adderall, there are various reasons why certain individuals still choose to do so.

  • Some may find the dopamine boost from both substances as an “appealing” high, although in fact mixing can be dangerous.
  • There is a common misconception that mixing Adderall with alcohol “cancels out” the negative feeling from both substances (for example, they think that Adderall can help delay the drowsiness that occurs after drinking alcohol). In fact, as mentioned above, this is not true and only results in the masking of any effects, which is dangerous.
  • Another misconception is that since both substances are legal, they are safe to mix, which is not true.

Individuals who are more prone to mixing both substances include students and young adults. Misuse of stimulants is already common among the population when they try to enhance academic performance, lose weight, or use it for recreational purposes. Research has shown[6] that college students who report recreational use of stimulants also report high rates of other substance use, especially alcohol.

Note that taking stimulants and other medications without a prescription, for uses not approved by your medical provider, or in higher doses than prescribed, is dangerous.

"If you take stimulant medication for ADHD during the workday, you may find yourself invited to social events like happy hour. In some situations, having a drink may be reasonable, but the risks vary depending on your health history, dose, and how your body metabolizes both alcohol and medication. For this reason, it’s important to talk with your healthcare provider before drinking so you can make an informed, safe decision."
Dr. Henry Bradford, MD
Medical provider at MEDvidi

Populations at Higher Risk

Specific populations are also more at risk for complications when combining alcohol and stimulants:

  • Older adults: their decreased metabolism causes alcohol to stay in their system longer.
  • Women: they typically have less body water than men, which causes alcohol to exist in higher concentrations in their bodies.
  • Patients with liver problems: their liver does not break down alcohol properly, so alcohol remains in their bodies longer.
Experiencing ADHD-like symptoms? Connect with licensed medical providers online for evidence-based, individualized treatment.

What Should Be Done If You’ve Mixed Adderall and Alcohol?

If you or someone you know took Adderall and alcohol together and started to experience confusion, shaking, an increased heart rate, unstable movements and impaired coordination, it’s important to seek help. Stop drinking, hydrate, monitor for further symptoms, and contact a healthcare provider if you have any concerns. Do not operate any motor vehicles, or do not allow another person who mixed Adderall with alcohol to operate them.

If any of the more serious side effects listed in the previous section occur, a doctor should be contacted immediately. Some relevant resources include the Substance Abuse and Mental Health Services Administration Hotline, Poison Control (1-800-222-1222), or 911. Be sure to share with the medical professional exactly what and how much alcohol was consumed. In some cases, inpatient treatment or outpatient rehab may be a consideration.

Conclusion

Do not mix Adderall with alcohol. Overall, do not drink alcohol while taking any stimulants, as a spectrum of dangerous side effects may occur. If you or someone you know may have taken Adderall and alcohol together, be sure to monitor symptoms and seek appropriate medical attention when needed.

If you are prescribed Adderall, only use your medication as directed and do not share your prescription. Talk to your provider before consuming alcohol when you take ADHD medications or if you have any other questions or concerns.

Frequently Asked Questions

Mixing the two can often dangerously mask the effects of either substance, making you feel like you’re not being affected. This can lead to increased consumption, a wide spectrum of harmful side effects[4] , or overdose.

It depends on different factors, such as gender, body weight, age, etc. The half-life of Adderall[7] is between 9-14 hours, which means only half the dose leaves your body during this time. So, a complete elimination of Adderall from your system generally takes several half-lives (often 2–3 days in healthy adults for the typical immediate-release dose), but this varies by formulation (Adderall XR will take longer to leave your system), the dose of Adderall, age, and liver/kidney function. It is safest to avoid alcohol entirely while taking Adderall.

It is generally advised to avoid alcohol during the whole course of treatment with Adderall. Consult your healthcare provider for individualized recommendations.

No. There is a common misconception that people can take Adderall with alcohol to “cancel out” the intoxication. However, this only results in the masking of any effects.

While it doesn’t directly increase intoxication, Adderall can make you unaware of how much you are drinking because it can mask the effects of alcohol. This can lead to you becoming more drunk than you anticipate.

While it doesn’t directly make you crave alcohol, Adderall can increase impulsive and risky behaviors, which include drinking to chase the dopamine high.

Sources

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7 sources
  1. DailyMed - ADDERALL- dextroamphetamine saccharate, amphetamine aspartate, dextroamphetamine sulfate, and amphetamine sulfate tablet. Nih.gov. Published 2024.
    Source link
  2. Martin D, Le JK. Amphetamine. PubMed. Published 2023.
    Source link
  3. CDC. Alcohol Use and Your Health. Alcohol Use. Published 2025.
    Source link
  4. CDC. Polysubstance Use Facts. Stop Overdose. Published April 30, 2024.
    Source link
  5. Simons R, Martens M, Ramaekers J, Krul A, Klöpping-Ketelaars I, Skopp G. Effects of dexamphetamine with and without alcohol on simulated driving. Psychopharmacology. 2011;222(3):391-399.
    Source link
  6. Egan KL, Reboussin BA, Blocker JN, Wolfson M, Sutfin EL. Simultaneous use of non-medical ADHD prescription stimulants and alcohol among undergraduate students. Drug and Alcohol Dependence. 2013;131(1-2):71-77.
    Source link
  7. Food and Drug Administration. ADDERALL ® (CII) (MEDICATION GUIDES ATTACHED) REVISED MARCH 2007 11001191 RX ONLY AMPHETAMINES HAVE a HIGH POTENTIAL for ABUSE. ADMINISTRATION of AMPHETAMINES for PROLONGED PERIODS of TIME MAY LEAD to DRUG DEPENDENCE and MUST BE AVOIDED. PARTICULAR ATTENT.; 2007.
    Source link
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Jessica Men
Written by:
Jessica Men
PharmD
Dr. Henry Bradford
Medical Reviewer:
Dr. Henry Bradford
MD
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