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The Causes, Symptoms, and Treatment of Comorbid Insomnia

Dorianne Green
Author:
Dorianne Green
Medical Writer
Dr. Michael Chichak
Medical Reviewer:
Dr. Michael Chichak
MD

Highlights

  • Comorbid insomnia, by definition, is distressingly poor sleep patterns that co-exist with other health problems.
  • Several medical or psychiatric conditions can co-exist with insomnia; these comorbidities may be the cause or effect of the poor sleep, or be completely unrelated.
  • Comorbid insomnia may present with feeling unrefreshed after sleeping, daytime tiredness, poor concentration, and difficulty regulating emotions.
  • Psychotherapy, self-help techniques, and medication are possible treatment options for comorbid insomnia. Importantly, if the co-occurring health condition is triggering insomnia, it also needs to be treated.

Ongoing poor sleep impacts both mental and physical health. However, sometimes, insomnia co-exists with other health conditions without affecting one another. Be it with or without mutual influence, when sleep issues co-exist with other conditions, the concept of comorbid insomnia comes in. Read on to explore its causes, symptoms, and treatment options.

Get assessed for insomnia and receive a personalized treatment plan online.

What Is Comorbid Insomnia?

The easiest way to understand what comorbid insomnia is, is to look at the words separately.

Insomnia means you’re unhappy with your sleep patterns, and it’s affecting your daily functioning negatively. You might feel that you’re:

  • Not getting enough sleep (poor quantity)
  • Not sleeping deeply (poor quality)

Insomnia can present as:

  • Having difficulty falling asleep
  • Waking often during the night
  • Sleeping continuously for some hours, but waking too early in the morning

Comorbid means to co-exist, co-occur, or be present at the same time.

So, comorbid insomnia is insomnia that occurs alongside any other diagnoses.

The Link Between Comorbid Insomnia and Co-existing Conditions

Insomnia and other conditions co-occur in three scenarios:

  1. They are completely separate diagnoses: unrelated, but co-existing
  2. Insomnia may trigger the co-existing condition
  3. The condition could lead to comorbid insomnia

Let’s take a closer look at some diagnoses that are related to their comorbid insomnia.

"A lot of time patients are surprised to learn that insomnia is not always a standalone condition. Sometimes, it's not simply due to difficulty sleeping but an underlying medical or psychiatric condition that is causing challenges either falling asleep or staying asleep. It's important to make sure that a thorough approach is taken, looking at the whole picture of the patient and making sure that other suspicions are ruled out. "
Dr. Michael Chichak
Medical provider at MEDvidi

Common Comorbidities Associated With Insomnia

Here is a list of comorbid conditions that are commonly linked to persistent insomnia.

Mental Health Conditions

Psychiatric or mental health conditions are the most frequent comorbidities in people with chronic insomnia. According to a study, about 8 out of 10 people[1] with a psychiatric diagnosis report sleep issues. Some common mental health comorbidities include:

Neurological Disorders

Comorbid insomnia is common in many brain-related disorders[2] , due to nerve damage or direct effects on the circadian rhythm. Some examples are:

  • Alzheimer’s disease and other dementias
  • Parkinson’s disease
  • Epilepsy
  • Traumatic brain injury
  • Stroke
  • Multiple sclerosis

Often, having a neurological illness triggers anxiety and depression, which aggravate the sleep issues.

Chronic Pain

Many people with chronic pain, regardless of the cause, report disturbed sleep[3] . Chronic pain/insomnia comorbidities cause a vicious cycle:

  • Physical discomfort[3] interrupts sleep
  • Poor sleep quality intensifies pain; possibly due to brain-based[3] changes

A few chronic pain conditions associated with insomnia are:

  • Rheumatoid arthritis
  • Osteoarthritis[4]
  • Fibromyalgia
  • Chronic headaches, including migraine and tension-types

Other Medical Conditions

Various medical conditions can lead to interrupted sleep due to symptoms such as frequent urination, difficulty breathing, or physical discomfort. Some illnesses associated with comorbid insomnia include:

  • Prostatic enlargement
  • Asthma and chronic obstructive pulmonary disease (COPD)
  • Diabetes
  • Heart failure
  • Gastroesophageal reflux disease (GERD)
"Comorbid insomnia is frequently overlooked; most of the time, the primary diagnosis gets the attention. An example would be acid reflux, where a patient complains of typical symptoms of burning, indigestion, and more symptoms after a heavy meal. However, it's much less frequent that the corresponding poor sleep gets the attention it needs. The challenge is, most times insomnia is treated as a completely separate complaint. If the root cause is appropriately addressed, oftentimes, the insomnia can take care of itself if it is secondary insomnia. "
Dr. Michael Chichak
Medical provider at MEDvidi

Comorbid Sleep Disorders

Insomnia itself might be a symptom of other sleep disorders[5] .

  • Obstructive Sleep Apnea: Gasping or choking due to a blocked airway wakes the person repeatedly.
  • Nightmare Disorder: Bad dreams cause poor sleep quality because of fear.
  • Restless Legs Syndrome: An uncontrollable urge to move the legs makes falling asleep difficult.
  • Rapid Eye Movement (REM) Sleep Behavior Disorder: A vivid dream event causes sudden waking with movement or talking.
  • External Circadian Rhythm Sleep-Wake Disorders: Jet lag or shift work are examples of this.

When Insomnia Is Unrelated to Co-existing Conditions

When there is no link between insomnia and co-existing conditions, trouble sleeping is usually due to insomnia disorder. Simply put, if insomnia is not the cause or the consequence of another condition, then it’s pure, long-standing insomnia; even if you have another standalone health condition as well.

To officially be diagnosed with insomnia disorder[6] , you need to have:

  • ✅ Dissatisfaction with your sleep patterns
  • ✅ Poor sleep for at least 3 months
  • ✅ Poor sleep at least 3 nights every week that is not better explained by another sleep-wake disorder or a co-existing physical or mental health condition
See a licensed healthcare provider online to get your symptoms assessed and receive personalized support.

Symptoms of Comorbid Insomnia to Look Out For

Let’s look at some symptoms of insomnia. If you’re having poor sleep quality or quantity, this could lead to:

  • Feeling unrefreshed in the morning
  • Experiencing daytime mental and physical fatigue, lethargy, and drowsiness

It makes sense then that if you’re mentally exhausted during the day, there will be knock-on effects[7] , such as:

  • Difficulty concentrating
  • Memory problems
  • Making mistakes
  • A higher risk of accidents
  • Mood changes

It is also critical to look out for symptoms of conditions that might lead to or be triggered by comorbid insomnia.

Can Medications Cause Insomnia?

Unfortunately, while treating one condition, some medications may affect our sleep cycles and cause insomnia. There are many reasons why this happens. For instance, they might stimulate the brain or affect neurotransmitters that impact sleep. In some cases, insomnia is a medication’s side effect, with no clear explanation.

Examples of medications that can cause insomnia include:

  • ADHD Stimulants: Ritalin (methylphenidate), Adderall (amphetamine and dextroamphetamine), and Vyvanse (lisdexamfetamine).
  • Selective Serotonin Reuptake Inhibitors (SSRIs): Prozac (fluoxetine), Paxil (paroxetine), and Zoloft (sertraline).
  • Steroids: Prednisone
  • Beta-Blockers: Propranolol (Inderal), used to treat high blood pressure and anxiety, can cause insomnia for some people.

However, everyone responds to medication differently, and insomnia is not an inevitable effect. If you suspect your trouble sleeping is associated with a new medication, talk with your healthcare provider about possible solutions.

Comorbid Insomnia Treatment and Prevention

Treating comorbid insomnia can be challenging because if a co-existing diagnosis triggers it, that condition needs to be treated first to improve sleep quality. But sometimes, it can be difficult to determine which comorbidity causes the other, which is why it is essential to see a healthcare provider for a workup.

Before that, you can try a few proven sleep hygiene[8] tricks to reduce the risk of and prevent comorbid insomnia:

  • Avoid caffeine intake after lunchtime.
  • Go to bed and wake up at the same time every day.
  • Get physically active, but not close to bedtime.
  • Don’t use mobile phones, watch television, or work in bed.
  • Ensure your bedroom is quiet, dark, and cool.
  • Listen to relaxing music, read a book, or have a warm bath to wind down before bedtime.

For all types of insomnia, even if a chronic illness causes it, therapy is the first-line treatment[9] .

Cognitive-Behavioral Therapy (CBT)

CBT is very effective for treating sleep disturbances. Commonly used CBT techniques[10] for resolving sleep problems include:

  1. Cognitive Restructuring: A therapist helps you identify and reduce worrying thoughts that are associated with and cause disrupted sleep patterns. 
  2. Sleep Restriction: A therapist will ‘prescribe’ a sleep schedule after reviewing your sleep diary, reducing the time you spend in bed to the actual number of hours you spend sleeping.
  3. Stimulus Control: People with insomnia start to fear bedtime, and this actually triggers the fight-or-flight response. When this happens, it helps to move out of the bedroom until you are sleepy again, helping you to associate your bed with comfort and relaxation rather than stress.

Relaxation Techniques

Based on the idea[10] that anxiety prevents sleep, these strategies are recommended because they are known to calm the fight-or-flight response.

  1. Deep Breathing: Because focusing on your breathing helps reduce anxiety, it could promote sleep[11] . There are many benefits of slow, deep breathing for the mind and body.
  2. Progressive Muscle Relaxation: Releasing tension from all joints and major areas of your body one by one may help you fall asleep faster.
  3. Mindfulness Meditation: Facilitates sleep by improving emotional regulation and reducing anxiety.

Medication

If CBT, relaxation, and sleep hygiene are slow to work, a healthcare provider might recommend short-term medication for comorbid insomnia. The FDA has approved the following prescription medications:

  • Sedative hypnotics (nonbenzodiazepines)
  • Benzodiazepines
  • Tricyclic antidepressants
  • Melatonin agonists
  • Barbiturates

Even though there are over-the-counter options like Benadryl (diphenhydramine) and Unisom (doxylamine), you should consult with a medical provider before taking them. Remember, it’s important to identify the comorbid insomnia trigger if there is one.

In Conclusion

Successfully treating comorbid insomnia requires targeting the sleep issues and the co-existing condition. This is why professional support is essential to optimize a personalized treatment plan for comorbid insomnia. If you want to discuss your symptoms in more detail and get a personalized treatment plan for insomnia online, contact licensed medical providers at MEDvidi by booking an online appointment.

Sources

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11 sources
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  2. Mayer G, Jennum P, Riemann D, Dauvilliers Y. Insomnia in central neurologic diseases – Occurrence and management. Sleep Medicine Reviews. 2011;15(6):369-378.
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  3. Mathias JL, Cant ML, Burke ALJ. Sleep disturbances and sleep disorders in adults living with chronic pain: a meta-analysis. Sleep Medicine. 2018;52:198-210.
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  4. De Baets L, Runge N, Labie C, et al. The interplay between symptoms of insomnia and pain in people with osteoarthritis: A narrative review of the current evidence. Sleep Medicine Reviews. 2023;70:101793.
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  5. What are Sleep Disorders? Psychiatry.org. Published 2024.
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  6. Substance Abuse and Mental Health Services Administration. Impact of the DSM-IV to DSM-5 Changes on the National Survey on Drug Use and Health [Internet]. Rockville (MD): Substance Abuse and Mental Health Services Administration (US); 2016 Jun. Table 3.36, DSM-IV to DSM-5 Insomnia Disorder Comparison.
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  7. McNamara S, Spurling BC, Bollu PC. Chronic Insomnia. [Updated 2025 Mar 28]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan-.
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  8. Singh R, Roy MM, Alvi A, Chouhan S, Goyal A, Rai NK. Sleep hygiene practices and its impact on sleep quality and mood. J Family Med Prim Care. 2025 Jul;14(7):2966-2973. doi: 10.4103/jfmpc.jfmpc_133_25. Epub 2025 Jul 21. PMID: 40814526; PMCID: PMC12349785.
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  9. Scott AJ, Correa AB, Bisby MA, et al. Cognitive Behavioral Therapy for Insomnia in People With Chronic Disease. JAMA Internal Medicine. Published online September 22, 2025.
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  10. Krystal AD, Prather AA, Ashbrook LH. The assessment and management of insomnia: an update. World Psychiatry. 2019 Oct;18(3):337-352. doi: 10.1002/wps.20674. PMID: 31496087; PMCID: PMC6732697.
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  11. Jerath R, Beveridge C, Barnes VA. Self-Regulation of Breathing as an Adjunctive Treatment of Insomnia. Front Psychiatry. 2019 Jan 29;9:780. doi: 10.3389/fpsyt.2018.00780. PMID: 30761030; PMCID: PMC6361823.
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Dorianne Green
Author:
Dorianne Green
Medical Writer
Dr. Michael Chichak
Medical Reviewer:
Dr. Michael Chichak
MD
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