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Highlights
- Wellbutrin is an antidepressant medication that can be used “off-label” as a treatment for ADHD.
- While Wellbutrin is not as effective as first-line ADHD medications, like stimulants, it is often chosen as a non-addictive option.
- Many people with ADHD also have depression or anxiety; as an antidepressant, Wellbutrin can help to address the symptoms of these co-existing conditions.
- Wellbutrin comes in three forms that vary in dosing frequency. For ADHD treatment, the extended-release version is most often prescribed.
- Wellbutrin has a longer onset of action than stimulants and can take several weeks to show the full benefits.
Wellbutrin (bupropion) is an antidepressant commonly used to treat depression and seasonal affective disorder and aid smoking cessation. However, Wellbutrin also holds off-label uses, including its ability to treat the symptoms of attention deficit hyperactivity disorder (ADHD). For those who do not tolerate stimulant medications, such as Adderall, Wellbutrin serves as an alternative.
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Effectiveness of Wellbutrin for ADHD
Wellbutrin works by decreasing the reuptake (or reabsorption) of norepinephrine and dopamine in the brain, hence increasing their concentration. So, when released from the nerve cells, these neurotransmitters stay active longer and can better send messages to other nerves. This becomes an advantage for those with ADHD, helping to reduce the severity of symptoms.
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The Pros and Cons of Using Wellbutrin to Treat ADHD
While stimulant medications are usually the first-line treatment for ADHD, Wellbutrin has its own advantages. For instance, unlike stimulants, it doesn’t carry a risk of dependence and abuse. Also, if taken alongside stimulants, Wellbutrin may increase their effectiveness.
Wellbutrin can also help with some comorbid mental health disorders. An estimated 18.6% of adults with ADHD
Along these same lines, having an underlying medical or psychiatric condition can make the prescription of a stimulant, which is the standard ADHD treatment, unideal. For example, sleep disorders, a history of dependency, or certain mood disorders can keep a patient from safely taking a stimulant—Wellbutrin offers a potentially safer alternative.
When it comes to the cons, Wellbutrin may not be as effective as stimulant medications and takes longer to produce effects. It also comes with an increased risk of suicidal thinking, especially in those under the age of 24. However, it is important to discuss potential effectiveness and risks with a healthcare provider—the choice of the medication highly depends on individual situations and needs.
If you’re experiencing suicidal or self-harming thoughts and require immediate assistance, contact a crisis hotline, such as 911, 988 suicide & crisis lifeline (toll-free), or Samaritans (116-123 or via chat).
Official Dosage Guidelines
Wellbutrin is available in three forms:
- Wellbutrin: an immediate-release formulation.
- Wellbutrin SR: a sustained-release medication that lasts for 12 hours.
- Wellbutrin XL: an extended-release formulation, lasts for 24 hours.
When used for ADHD, Wellbutrin is often prescribed in the XL form, although the specific dosage differs based on individual health needs.
The FDA-approved dosage options for each form of Wellbutrin include:
- Immediate-release: 75 mg and 100 mg
- Sustained-release: 100 mg, 150 mg, and 200 mg
- Extended-release: 150 mg and 300 mg
Since Wellbutrin is not FDA-approved for ADHD and is prescribed off-label for this condition, doctors choose a suitable dose on a case-by-case basis.
Wellbutrin formulations and dosages are provided for informational purposes only. Please consult your healthcare provider and follow their instructions.
Risks and Considerations
There are some possible side effects of Wellbutrin, including:
- Low appetite
- Dizziness
- Difficulty sleeping
- Blurry vision
- Dry mouth
- Agitation
- Increased anxiety
- Constipation
- Nausea or vomiting
- Sweating
- Restlessness
- Headache
It’s estimated that at least
Certain populations should not take Wellbutrin. For instance, those who are pregnant or planning to become pregnant should discuss alternative forms of treatment with their healthcare provider, as Wellbutrin is not considered safe to take during pregnancy or when breastfeeding.
Wellbutrin also contains a black box warning due to the possibility of suicidal thoughts while taking Wellbutrin, especially in children, teens, and young adults. Also, it has not been shown to be safe and effective for use in those under the age of 18, and there is no FDA-approved dosage for children.
Knowing the possible side effects and contraindications of Wellbutrin, it is crucial that you discuss the benefits and risks with a healthcare provider and remain in close contact while taking the medication.
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Why Is Using Wellbutrin for ADHD Considered “Off-Label”?
The main FDA-approved use of Wellbutrin is major depressive disorder (MDD). So, when Wellbutrin is prescribed for ADHD, it is prescribed “off-label.” This is a term applied when medications are recommended for a reason outside of their FDA-approved uses.
For those diagnosed with ADHD, doctors usually prescribe stimulant medications. An antidepressant like bupropion can be considered if someone doesn’t respond well to stimulants or can’t tolerate them. Wellbutrin can help those with ADHD to manage the symptoms. It was proved by different studies, but this still remains an off-label application.
Learn more: Medications for Adults With ADHD and Anxiety
Comparing Wellbutrin to Adderall
Wellbutrin and Adderall belong to different medication classes, so they differ in their mechanisms of action, the onset of effects, and other factors. Each medication can be preferable in specific cases. For example, it’s important to consider the following:
- Some people may experience unpleasant side effects while taking stimulants, with Adderall having side effects that include appetite suppression, increased heart rate, and raised blood pressure. Since Wellbutrin functions differently than Adderall, some people may find that it produces fewer negative side effects.
- Adderall is a controlled substance, which means it has a potential for abuse. This can make it an unsuitable option for certain individuals, including those with a history of substance use disorder. If misused, Adderall can be taxing on the lungs, heart, and vascular system while also producing serious side effects such as tremors, anxiety, hostility, insomnia, and psychosis. Wellbutrin is a non-addictive alternative.
However, Adderall is a recognized treatment for ADHD symptoms and is commonly prescribed because of its effectiveness. Wellbutrin, on the other hand, is more of an alternative rather than a typical initial choice for ADHD.
How Long Does Wellbutrin Take to Work for ADHD?
It can take some time for Wellbutrin’s full benefits to be noticed, especially when compared to stimulant medication that offers a faster onset. In comparison, it may take
Once the ideal dose has been found, it can take 4 to 6 weeks until one experiences the full benefits of bupropion. Signs that Wellbutrin is working can include increased appetite, improved mood, and better sleep, as well as a reduction in other ADHD symptoms.
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Alternative Treatments for ADHD
The FDA has approved three non-stimulant medications to treat ADHD in adults: Intuniv, Strattera, and Kapvay. Like Wellbutrin, they are potentially less effective than stimulants but have a low risk of addiction.
However, the most common medications for ADHD include stimulants like Adderall, Concerta, Ritalin, or Vyvanse. If non-stimulants are not working, and there are no contraindications for stimulant medicines, a doctor may prescribe one of these.
In addition to medication, there are other approaches to ADHD treatment, including behavioral therapy. It focuses on creating healthier behavioral patterns and changing the way a person responds to triggers, stressful situations, and different challenges posed by ADHD. Also, a healthcare provider may recommend lifestyle changes. Physical activity, improved sleep hygiene, a balanced diet, and various relaxation and mindfulness techniques can be of great support for medication management and psychotherapy.
Summing Up
While Wellbutrin is not a first-line treatment for ADHD, it may be helpful in treating this condition in some individuals. Its differing mechanism of action, as a norepinephrine dopamine reuptake inhibitor, can produce fewer side effects than stimulants. It can also be helpful if one has co-existing conditions, such as depression or anxiety. Contact MEDvidi today to get connected with a healthcare provider, go through an assessment, and receive personalized treatment online.
Frequently Asked Questions
Is Wellbutrin a stimulant?
Wellbutrin is a non-stimulant medication; it belongs to a class of antidepressants. Although typically prescribed for depression treatment, it can be used off-label for ADHD due to its mechanism of action.
Is Wellbutrin SR or XL better for ADHD?
If a healthcare professional chooses Wellbutrin for ADHD treatment, they usually prescribe Wellbutrin XL which requires once-daily administration. However, it may depend on the individual needs and health specifics, so remember to discuss it with your healthcare provider and follow their instructions.
What does it mean if Wellbutrin makes you tired?
Wellbutrin, like some other antidepressants, can cause tiredness, sleepiness, and fatigue in some patients. It can mean your body adjusts to the medication, but if drowsiness is severe, consult with your healthcare provider. They may tell you how to cope with the symptom better, how long it can take to overcome it, and in some cases, change your treatment regimen.
Does Wellbutrin help with focus?
Different studies show that Wellbutrin
Can Wellbutrin make ADHD worse?
There is no strong evidence suggesting Wellbutrin can worsen ADHD. However, individual responses may vary, as well as the presence of specific side effects or comorbid mental health conditions. If you feel like your ADHD symptoms are getting worse, discuss it with your healthcare provider on your next follow-up appointment to adjust the treatment plan.
How to get a prescription for Wellbutrin?
To get a prescription for Wellbutrin, you have to consult with a healthcare professional in person or online to get your symptoms assessed and receive a diagnosis. If Wellbutrin appears to be the most appropriate treatment option, your healthcare provider will write you a prescription or send it directly to your pharmacy.
