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Mood Disorders: Types, Causes, Symptoms & Treatment

Dorianne Green
Author:
Dorianne Green
Medical Writer
Dr. Henry Bradford
Medical Reviewer:
Dr. Henry Bradford
MD

Highlights

  • Mood disorders are mental health conditions characterized by striking disturbances of mood and motivation.
  • The mood changes seen in mood disorders can be severe lows (depressive episodes) or severe highs (manic episodes).
  • There are two broad types of mood disorders, depressive and bipolar and related disorders, each having subtypes.

Mood, be it sadness, happiness, contentment, or irritability, influences your behavior. And during the course of a day, it is entirely normal to have mild mood swings depending on what’s happening around you. But ‘mood disorder’ implies a problem, so when do changes in feelings become an issue? 

This article will examine examples of mood disorders, their symptoms, diagnosis, and treatment.

Feeling low or emotionally unstable for a while? See a licensed healthcare provider for an online mental health assessment.

What Are Mood (Affective) Disorders?

The definition of a mood disorder includes a striking mood disturbance or instability, which can either be an extreme low (called depression) or a severe high (called mania).

The term ‘affective disorders’ is an older term for mood disorders, which some doctors may still use.

When we talk about types of mood disorders, it’s usually the two umbrella categories: depressive and bipolar and related disorders. They are defined and diagnosed using the two main symptom groups: depressive and manic episodes.

Symptoms of Mood Disorders

Let’s chat about these depressive and manic mood symptoms before we tackle the disorders themselves. We’ll look at changes in emotions and thinking, as well as physical signs and symptoms.

Depressive Episodes

Depressive episodes[1] are extremely low moods[2] that affect how a person feels, thinks, and functions.

Extreme or inappropriate emotional presentations:

  • Sadness
  • Emptiness
  • Hopelessness
  • Irritability
  • Experiencing no interest or pleasure

Changes in thinking:

  • Poor concentration
  • Poor memory
  • Negative thoughts, for example, “I’m worthless,” or “What’s the point of life?”
  • Brain fog

Physical manifestations:

  • Exhaustion
  • Sleeping too much or too little
  • Eating more or less than usual
  • Aches and pains, for example, headaches or stomach issues
"Unmanaged mood disorders can significantly impair daily functioning and overall well-being. While conservative measures may help in milder cases, moderate to severe conditions often require medical treatment. Accurate diagnosis is essential, as treatment approaches for unipolar depression differ markedly from those for bipolar disorders."
Dr. Henry Bradford, MD
Medical provider at MEDvidi

Manic (or Hypomanic) Episodes

Manic (or hypomanic) episodes[3] are inappropriate high or ‘elevated’ moods[2] . The difference is that a manic episode is severe, disruptive, and lasts longer[3] than a hypomanic episode, which is a milder form.

Manic EpisodeHypomanic Episode
  • Marked or debilitating effect on functioning at home and work

OR

  • Requires hospitalization

OR

  • Psychotic features are present
  • Slight to moderate impact on functioning
  • A least 1 week
  • Any duration if hospitalization is present
  • At least 4 consecutive days

The person having the manic episode is often not aware of what is happening[3] , while those around them usually observe the manic symptoms and signs of the mood disorder.

Shared Symptoms in Both Hypomania and Mania

Extreme or inappropriate emotional presentations:

  • Cheerfulness
  • Optimism
  • High energy
  • Confidence
  • Friendliness
  • Irritability
  • Extreme mood swings and anger

Changes in thinking:

  • Racing thoughts
  • High distractibility

Physical manifestations:

  • Increased talkativeness
  • Rapid speech
  • A decreased need for sleep
  • Restlessness, like pacing or tapping
  • Increased impulsiveness
  • Over-working
What causes mood disorders

Commonly Seen in Manic Episodes

Changes in thinking can also involve psychotic features:

  • Delusions: Believing things that aren’t real.
  • Hallucinations: Seeing, hearing, or smelling things that aren’t real.
  • Grandiosity: An exaggerated sense of one’s own importance, abilities, or power. It is not usual self-confidence. Examples may be believing that they: 
    • Don’t need to study because they’re more intelligent than the professors.
    • Can start multiple businesses with no plan or finances.
    • Can claim they can heal people with their minds.
Get assessed for mood disorders online and receive individualized recommendations.

Types of Mood Disorders

Below is a list of the different mood disorders, providing you with a clear picture, before we discuss them in detail.

1. Depressive Mood Disorder Types (the more common mood disorders)

  • Major depressive disorder (MDD)
  • Persistent depressive disorder or dysthymia (PDD)
  • Premenstrual dysphoric disorder (PMDD)
  • Disruptive mood dysregulation disorder (DMDD)
  • Seasonal affective disorder (SAD)
  • Substance/medication-induced depressive disorder
  • Depressive disorder due to another medical condition
  • Unspecified depressive disorder

2. Bipolar Mood Disorder Types

  • Bipolar I disorder
  • Bipolar II disorder
  • Cyclothymic disorder
  • Substance/medication-induced bipolar disorder
  • Bipolar disorder due to another medical condition
  • Unspecified bipolar disorders

3. Unspecified Mood (Affective) Disorder

Depressive Disorders

Major Depressive Disorder (MDD)

Often considered the most common mood disorder, MDD is diagnosed when at least five out of the nine symptoms listed below are present for at least 2 weeks and cause poor functioning in daily life.

  1. Sad mood
  2. Insomnia
  3. Feelings of guilt
  4. Low energy levels
  5. Poor concentration
  6. Poor or increased appetite
  7. Finding no enjoyment or pleasure in things that were pleasant before
  8. Being restless or sluggish
  9. Recurrent self-harm or suicidal thoughts or acts

A few facts about depression:

  • Major depressive disorder is the most common type of mood disorder in both men and women. But women are twice[2] as likely to have MDD during their lifetime compared to men.
  • The lifetime prevalence of MDD is approximately 5-15%[2] .
  • In a year, about 7 out of 100 U.S. adults[2] will have depression.
  • Depression is one of the leading causes of disability worldwide.

6 out of 10 people[1] with depression don’t seek help.

Persistent Depressive Disorder (PDD or Dysthymia)

PDD or dysthymia[4] is diagnosed when a depressive episode is not severe enough to be diagnosed as MDD, but lasts a very long time: at least two years in adults and one year in children and adolescents.

Premenstrual Dysphoric Disorder (PMDD)

This mood disorder affects females, usually starting a week before menstruation and lasting three to seven days after the first day. Rapid mood swings are a hallmark feature of this condition, as are depressive mood, anxiety, and physical symptoms.

Seasonal Affective Disorder (SAD)

Depressive episodes at the change of seasons[5] characterize SAD. ‘Winter depression’ is more common, usually starting around fall, when it is colder and days are shorter, and improving when spring arrives.

Disruptive Mood Dysregulation Disorder (DMDD)

It is a new diagnosis that appeared first in the DSM-5-TR and only affects children and adolescents. People with DMDD have frequent anger outbursts and irritability out of proportion to the situation[2] .

Other Specified and Unspecified Depressive Disorders

These are depressive episodes that don’t fit into the conditions discussed above.

If you’re experiencing suicidal or self-harming thoughts and require immediate assistance, contact a crisis hotline, such as 911, 988 suicide & crisis lifeline (toll-free), or Samaritans (116-123 or via chat).

Bipolar Disorders (BD)

Bipolar I

Bipolar I is diagnosed if the person with the mood disorder has at least one manic episode[6] ; nothing else is required. However, depressive and hypomanic episodes might also occur.

Bipolar II

Bipolar II is diagnosed if the person with the mood disorder has at least one hypomanic episode[6] and at least one major depressive episode. In the past, this was referred to as manic depression.

"Bipolar disorder, particularly bipolar II, is among the most frequently misdiagnosed conditions in psychiatry. Several other disorders can mimic its symptoms, including trauma-related conditions, personality disorders, anxiety disorders, and substance use disorders. For individuals diagnosed with bipolar II who have not responded well to standard treatments, obtaining a second opinion can be valuable to reassess the accuracy of the diagnosis and explore alternative treatment options. "
Dr. Henry Bradford, MD
Medical provider at MEDvidi

Cyclothymia

Cyclothymia is a tricky one; essentially, it consists of depressive and hypomanic symptoms that don’t meet the diagnosis[7] for bipolar I, bipolar II, or MDD. It also starts early in life and is notoriously difficult to diagnose. Because of the rapid ups and downs, it falls under bipolar disorders.

Other Specified and Unspecified Bipolar Disorders

These are presentations that don’t fit into the bipolar-type conditions discussed above.

A few facts about bipolar disorder:

  • Men and women are usually equally affected[6] by bipolar disorders.
  • In a year, about 3 out of 100 U.S. adults[2] will be diagnosed with bipolar disorder.
  • The lifetime prevalence of bipolar disorder is about 4%[3] .

In 7 out of 10 people[6] diagnosed with bipolar disorder, the symptoms first present between the ages of 15 and 25.

Unspecified Mood Disorder

Mood disorder not otherwise specified (NOS)[8] might be diagnosed when it is difficult to choose between an unspecified depressive disorder and an unspecified bipolar disorder.

If any of these symptoms or patterns sound familiar, and they’ve been affecting your daily life, consider consulting a professional.

Risk Factors and Causes of Mood Disorders

The exact cause of bipolar disorder[6] is unknown, but, as with depressive disorders, researchers believe that multiple interacting factors contribute to their development.

Brain Chemistry Factors

Certain neurotransmitters, including serotonin, norepinephrine, and dopamine, play a crucial role in regulating mood. Low availability of serotonin[1] in ‘the right places’ in the brain may cause depression. Additionally, imbalances in these neurotransmitters are also believed to contribute to BD; however, no specific cause[6] has been identified.

Genetic Factors

A positive family history of mood disorders is a substantial risk factor. So, children and siblings of people with mood disorders are more likely to be diagnosed with the condition themselves.

Social Factors

Childhood emotional abuse or neglect[6] has a strong connection to the later development of BD and depression. Also, at least 6 out of 10 patients with BD[6] report a “stressful life event”, such as the death of a loved one, divorce, or financial difficulties, within 6 months of an episode.

Medical Conditions and Medication

Medical Conditions

A long-term illness, for example, cancer, severe arthritis, or lung problems, can cause depressive symptoms in patients because they are no longer able to do what they used to. Also, certain medical conditions can directly trigger mood disorders; some examples of these include vitamin B12 and D deficiencies, HIV, syphilis, brain tumors, and multiple sclerosis (MS).

Hormonal imbalance can also cause physical and psychological problems. For example, abnormal cortisol, reproductive, thyroid, and growth hormone[9] levels may contribute to or exacerbate mood symptoms. 

Medications

Sometimes, medication or illicit drugs can trigger depressive or manic episodes; your healthcare provider will consider this when reviewing your history. A few examples are steroids, birth control pills, blood pressure medication, epilepsy medication, alcohol, drugs of abuse, sleeping tablets, and even certain antibiotics.

Other Conditions Commonly Diagnosed with Mood Disorders

Often, other mental health conditions coexist with mood disorders. Here are a few examples:

Co-occurring conditions can complicate matters for a few reasons:

  • Sometimes, the symptoms overlap, making diagnosis tricky.
  • When there are multiple mental health conditions, finding a treatment to cover all the symptoms is often difficult, making the road to recovery longer. 

Diagnostic Process for Mood Disorders

  1. Booking a Consultation. The first step to getting a mood disorder diagnosis is to make an appointment with a healthcare professional and have an assessment.
  2. Chatting Through Your Symptoms. A healthcare provider will listen to your story and ask specific questions about symptoms that point towards manic and depressive episodes. They may also use specific mood disorder questionnaires to aid in the diagnosis.
  3. Taking Health History. They will take a family history and ask about your current and past medications and medical conditions.
  4. Having an Examination and Investigations. If the healthcare professional suspects another medical condition is the cause, they may refer you for special investigations, such as brain scans or blood tests, to rule it out.
  5. Making the Diagnosis. With all this information, they will use the Diagnostic and Statistical Manual of Mental Disorders (DSM-5-TR) to decide:
  • If there is a mood disorder present
  • What type and subtype is it

Once this is confirmed, a healthcare provider will decide on appropriate treatment options.

Mood Disorder Treatment

Treatments for mood disorders usually include medications and mental health therapies.

Medications

There are three main classes of medications used to treat mood disorders.

Medications for mood disorders

Antidepressants

Antidepressant medications mainly treat depressive disorders, although occasionally they are used for the depressive episodes seen in bipolar disorders in combination with mood stabilizers.

SSRIs (selective serotonin reuptake inhibitors) and SNRIs (serotonin-norepinephrine reuptake inhibitors) are the most commonly prescribed antidepressants due to their better safety profile and tolerability. It usually takes them 4 to 6 weeks to start working.

Mood Stabilizers

Mood stabilizers help to prevent severe mood swings and manic episodes; they are often first-line for bipolar disorders[2] . The most commonly prescribed ones are antiepileptic medications and lithium.

Antipsychotics

Antipsychotics are another first-line option[6] , as many are also mood stabilizing; they have the added benefit of controlling delusions and hallucinations. One well-known example is aripiprazole (Abilify).

See a healthcare provider to get individualized help, including an online prescription, if appropriate.

Mental Health Therapy

Different psychotherapies are helpful to treat mood disorders; the more common ones include:

Cognitive-Behavioral Therapy (CBT)

CBT is the most widely used therapy for mood disorders. It helps patients identify and change thoughts that are affecting their moods, allowing them to modify their behavior. 

Interpersonal Therapy

This therapy focuses on the fact that the world and people around us affect our emotions[10] . It helps people with mood disorders, particularly depression, work through trigger situations.

Family Therapy

Firstly, this type of therapy helps patients understand how their condition impacts their family. Secondly, it educates family members about the condition, helping them to be more tolerant and supportive. And finally, if the condition’s trigger was a family stress, therapy can help resolve the situation. 

Psychoanalytical Therapy

Psychoanalysis[11] focuses on revealing and resolving unconscious thoughts and emotions related to childhood events that might have contributed to the current mood disorder. 

Less Common Treatment Options

There are some additional treatment methods sometimes used for severe forms of mood disorders; they include:

Electroconvulsive Therapy (ECT)

ECT involves passing electrical currents through electrodes into the brain, inducing a mild seizure. Usually, it is used because the medications available haven’t helped. 

Vagus Nerve Stimulation (VNS)

Electrical impulses stimulate the vagus nerve to regulate mood symptoms, and it is FDA-approved for[12] the treatment of resistant depression.

Transcranial Magnetic Stimulation

It involves sending short bursts of magnetic energy to the targeted brain regions to manage mood disorders and is FDA-approved[9] for the treatment of resistant depression.

Light Therapy

People with SAD (seasonal affective disorder) are exposed to light that mimics natural sunlight.

Lifestyle Changes

Making small adjustments in daily life activities may speed up the recovery process. 

Regular Exercise

Physical exercise boosts physical and mental health, justifying the proverb, ”A healthy mind in a healthy body.” It doesn’t have to be strenuous exercise; a daily 20-30 minute walk can also be effective if done consistently.

Balanced Diet

Cutting back on junk food and switching to organic foods, such as vegetables, whole grains, and white meat, can have a profoundly positive impact on mental health.

Yoga and Other Relaxation Techniques

Yoga, mindfulness, breathing exercises, and meditation are effective for lowering stress levels and boosting happy chemicals in the brain.

Avoiding Smoking, Vaping, and Alcohol Consumption

Smoking or vaping and alcohol consumption can make a person feel depressed and anxious when the alcohol and nicotine levels drop. Alcohol consumption should be cut down to less than 2 units per day for men, and 1 unit per day for women, although even small amounts carry health risks.

How to treat mood disorders: additional tips

Outlook and Prognosis

Unfortunately, there is no way to predict whether treatment will be effective, how long it will take to control symptoms, or how long the remission will last. This is because not everyone’s body or mood disorder presentation is identical. However, there are a few trends:

  • About 5 to 10 percent of the patients with MDD eventually develop bipolar disorder[9] .
  • MDD often recurs[9] , with the likelihood of a future relapse increasing with every episode. This is why ongoing management is important.

People with mood disorders might have more difficulties in the future[9] if they have:

  • More than one mental health condition
  • A personality disorder
  • Multiple hospitalizations
  • A mood disorder diagnosed later in life

On the other hand, they have a better outlook[9] if they have:

  • Mild symptoms
  • No psychotic features, including delusions or hallucinations
  • Been taking their medication correctly and long-term 
  • Regular follow-ups with their mental health professionals

When to Seek Help

Early diagnosis and treatment improve the outcome, so if you think that you might have a mood disorder and are experiencing any of the following ‘mood disorder warnings’, seek help as soon as possible:

  • Your extreme low or high moods are affecting relationships and functioning at home or work.
  • You are using alcohol or illicit drugs.
  • You are seeing or hearing things that no one else does.
  • You believe something is true, even though there is clear evidence it isn’t
  • You are thinking about self-harm or suicide.
  • You are thinking about harming someone else.

At MEDvidi, you can see a licensed healthcare provider who will start the process by conducting an accurate online mental health assessment and making a diagnosis. Should this be a major depressive disorder, they will create a customized treatment plan and continue to monitor the progress throughout the recovery phase. For bipolar and related disorders, MEDvidi’s team can make a diagnosis and recommend next steps, helping to get you to the appropriate mental health professionals.

Book an appointment and experience high-level care from the comfort of your home.

Mood Disorders FAQs

Doctors diagnose mood disorders by carefully assessing symptoms through questionnaires and health history review, ruling out other possible medical causes, and ensuring that the DSM-5-TR criteria are met.

Mood disorders and personality disorders are not similar, although they are both recognized mental health conditions; their course and predominant symptoms differ. Mood disorders primarily affect emotions, whereas personality disorders directly disrupt behavior and thinking patterns.

According to statistics, an estimated 9.7% of US adults are likely to be diagnosed with a mood disorder in any given year. The ratio is higher for females than for males.

No, anxiety is not considered a mood disorder. However, an uncontrolled lifelong anxiety disorder might trigger a mood disorder if a person’s anxiety is affecting their daily functioning, making them feel extreme sadness. 

Mood disorder episodes often recur and may be lifelong. The likelihood of a future relapse increases with every new episode, so it is important to get a diagnosis early, take treatment correctly, and follow up regularly.

If a severe mood disorder interferes with the patient’s daily life to the extent that they cannot function at all, then it might qualify as a disability. It may also entitle patients to apply for Social Security Disability (SSD) benefits.

Yes, untreated ADHD can increase stress and anxiety levels that may ultimately lead to the development of a mood disorder.

There are two broad groups of mood disorders, the depressive and bipolar types. The depressive group includes: major depressive disorder (MDD), persistent depressive disorder or dysthymia (PDD), premenstrual dysphoric disorder (PMDD), disruptive mood dysregulation disorder (DMDD), and seasonal affective disorder (SAD). The bipolar group includes: bipolar I disorder, bipolar II disorder, and cyclothymic disorder, among others.

The most common mood disorder is major depressive disorder, which affects seven out of every 100 adults in the US.

Cyclothymia is often considered the rarest mood disorder according to statistics; however, there is limited data about the unspecified type and subtypes.

There isn’t one specific mood disorder that is hardest to live with, as every individual’s situation is different. The outcome depends on a few factors, including the severity of the symptoms and the availability of support systems and treatment options.

Mood disorders are usually influenced by multiple factors, for example, a family history, stressful life events, an abusive childhood, certain medical conditions, medications, and substance abuse.

Mental health conditions that might present with similar symptoms to bipolar disorders include: borderline personality disorder, and schizoaffective disorder.

A mood disorder can impact relationships and the person’s ability to perform routine chores and work tasks, due to changes in thinking, energy levels, and motivation.

Yes, major depressive disorder is a mood disorder; one of its depressive episodes could indicate MDD alone, or form part of a bipolar diagnosis, if the person has also experienced manic episodes.

Sources

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12 sources
  1. Chand SP, Arif H. Depression. [Updated 2023 Jul 17]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan
    Source link
  2. Sekhon S, Gupta V. Mood Disorder. [Updated 2023 May 8]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan
    Source link
  3. Dailey MW, Saadabadi A. Mania. [Updated 2023 Jul 17]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan
    Source link
  4. National Institute of Mental Health. Persistent Depressive Disorder (Dysthymic Disorder).
    Source link
  5. Munir S, Gunturu S, Abbas M. Seasonal Affective Disorder. [Updated 2024 Apr 20]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan
    Source link
  6. Jain A, Mitra P. Bipolar Disorder. [Updated 2023 Feb 20]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan
    Source link
  7. Bielecki JE, Gupta V. Cyclothymic Disorder. [Updated 2023 Jul 17]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan
    Source link
  8. American Psychiatric Association. Unspecified Mood Disorder.; 2022.
    Source link
  9. Bains N, Abdijadid S. Major Depressive Disorder. [Updated 2023 Apr 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan
    Source link
  10. Markowitz JC, Weissman MM. Interpersonal psychotherapy: principles and applications. World Psychiatry. 2004 Oct
    Source link
  11. Psychoanalytic Therapy - an overview | ScienceDirect Topics.
    Source link
  12. Austelle CW, O'Leary GH, Thompson S, Gruber E, Kahn A, Manett AJ, Short B, Badran BW. A Comprehensive Review of Vagus Nerve Stimulation for Depression. Neuromodulation. 2022 Apr
    Source link
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Dorianne Green
Author:
Dorianne Green
Medical Writer
Dr. Henry Bradford
Medical Reviewer:
Dr. Henry Bradford
MD
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