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Does Zepbound Cause Hair Loss?

Dorianne Green
Written by:
Dorianne Green
Medical Writer
Dr. Michael Chichak
Medical Reviewer:
Dr. Michael Chichak
MD
The medications listed on this website are provided for informational purposes only.

Their inclusion does not guarantee they will be prescribed to any individual, as treatment decisions are ultimately at the discretion of healthcare providers. Healthcare providers may prescribe other medications or recommend non-pharmacological treatment based on the patient’s unique health circumstances and needs. Read more

Zepbound (tirzepatide) has a boxed warning[1] , the most serious type of warning from the Food and Drug Administration (FDA). The medication causes C-cell tumors in rodents and is contraindicated in patients with a personal or family history of MTC or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Remember to discuss the risks with your healthcare provider.

You’d really like to lose some weight, and after research, you’re considering a weight loss injection. But people on social media report losing hair on Zepbound, which is the one you are most interested in, and that worries you. This article discusses everything about hair loss and Zepbound, as well as why there’s a link, what to expect, and how to prevent it.

Highlights

  • Hair loss is a relatively commonly reported side effect of Zepbound.
  • The mechanism of hair loss is due to telogen effluvium, a process triggered by anything that disrupts the hair follicle.
  • In the case of Zepbound, the leading trigger of telogen effluvium and hair loss is thought to be rapid weight loss, causing physiological stress.
  • Zepboud causes temporary hair shedding, which reverses once weight stabilizes or the medication is stopped.

Can Zepbound Cause Hair Loss?

Unfortunately, hair loss is a common side effect of Zepbound (tirzepatide); at least 5 out of every 100 patients experience it, according to the prescribing information, and it happens more frequently in females[2] than males.

Tirzepatide hair loss is usually temporary and typically starts at least three months after starting Zepbound; hair shedding is more frequent in patients treated for diabetes than in people requiring weight management.

Importantly, hair loss is not only seen with Zepbound but also with other GLP-1 receptor agonist weight loss medications, such as Mounjaro, Ozempic, and Wegovy.

Let’s take a closer look at why.

Get all your questions about Zepbound answered: see a licensed medical provider online for an individual weight loss plan.

Why Does Zepbound Cause Hair Loss?

There are many theories as to why Zepbound affects hair health, and they all center around something with a fancy name, telogen effluvium (TE) hair loss. To understand this, you need to quickly learn about how hair grows[3] .

Most healthy adults have 80,000 to 120,000 hairs on their heads that go through the following phases:

  1. Growth (anagen) phase: This lasts 2 to 6 years, and usually, 9 out of 10 hair follicles are in this phase.
  2. Resting (telogen) phase: After growing, the hair follicle becomes inactive and rests for about 3 months; in normal conditions, 1 out of 10 hairs is in this phase.
  3. Shedding phase: Inactive or dead hair drops from the scalp; as a rule, this is about 100 hairs a day. 

Hair loss happens[3] when anything, not just medication, impacts hair follicle health during the growth phase, so more than half of the growth-phase follicles move into the resting phase. After about three months of inactivity, when this phase ends, hair shedding increases dramatically.

Assuming 100,000 hairs on the head

 NormalAfter trigger/stress
Growth90,000<= 50,000
Resting10,000> 50,000
(3 months pass)  
Shedding100/d> 500

Some of the factors that may interfere with hair follicle health, triggering hair loss, include:

  • Hormone changes, like in pregnancy or menopause.
  • Nutrient deficiencies, such as Vitamin D and iron.
  • Chronic medical conditions, for example, thyroid problems and autoimmune diseases.
  • Emotional stress, like divorce or the death of a loved one.
  • Physical stress, such as surgery or injury.
  • Medication (can directly act on the hair follicle or affect it indirectly by causing one of the triggers above).
Hair loss is a common side effect of weight loss, particularly rapid one. The body looks at hair production as an optional process that can be discontinued when in a calorie deficit or an extremely stressful state. The body will divert energy that is dedicated to hair production and reallocate it to other more important processes, such as immune system support, bone turnover, and other primary metabolic functions. Considering this, patients do report hair loss the side effect of Zepbound — likely, because of rapid weight loss that they are experiencing due to Zepbound. In any case, talk with your doctor to make sure that the right decision is made in your specific situation.
Medical provider at MEDvidi

Look at Zepbound as an example; here are some ways that it might affect hair growth.

Direct Action of Zepbound

One theory is that tirzepatide directly disrupts the normal hair growth cycle.

Higher Dosages

Zepbound hair thinning, like many other side effects, is more likely to happen at higher doses.

Stress on the Body

Both physical and emotional stress can cause hair loss; this can happen because the stress hormone cortisol increases, and prevents the hair follicle cells from dividing[4] and growing, pushing them into the resting phase. Significant weight loss is a physical stress on the body, and it’s thought to be the main contributing factor to Zepbound hair loss.

Caloric Restriction

Zepbound is a medication that suppresses appetite and reduces cravings for sugars and carbohydrates. This low-calorie diet decreases the instantly available energy to fuel hair follicle growth, but can also trigger the stress response[5] .

Nutritional Deficiencies

Again, a decreased appetite may lead to skipping meals; not eating enough of certain foods might result in nutrient imbalances and unhealthy hair follicles. Another reason for Zepbound deficiencies is decreased nutrient absorption caused by vomiting and delayed gastric emptying.

Another contributing factor to hair loss is nutritional deficiencies. Keep in mind that during a calorie deficit, sometimes, essential micronutrients are cut from the diet unintentionally. Some of these micronutrients are important for hair growth, so, because they are insufficiently present in a diet during some weight loss attempts, hair loss can happen.
Medical provider at MEDvidi

Hormonal Changes

Estrogen levels drop in women who lose excessive weight, and low estrogen[6] , as seen during menopause, can cause hair loss in females.

Brings Out Underlying Conditions

Sometimes, preventing hair loss may be difficult, as Zepbound weight loss may accelerate pre-existing conditions. One example is premature androgenetic alopecia, or male pattern baldness[7] , which can affect men and women.

Have ongoing follow-ups with a provider to monitor your response to medication and adjust your treatment if needed.

Is Zepbound Hair Loss Permanent?

Hair loss due to Zepbound is a temporary shedding, and hair usually grows back completely, without any treatment, when the trigger disappears or the body adjusts. It is a long process; from the time the trigger stops, it’s typically about 3 to 6 months before the hair starts to grow again. And then, it lengthens at about half an inch a month[8] .

If you have hair loss on Zepbound, and it’s not following this timeline, please consult a healthcare professional.

There are no statistics on persistent hair loss from Zepbound, implying that if such cases occur, they are extremely rare. 

How to Prevent and Treat Zepbound Hair Loss

To stop hair loss on Zepbound, you must decrease the trigger intensity and ensure your hair follicles are in the best possible health. Here are some ways to do this:

Address Any Zepbound Triggers

Make Sure You Don’t Lose Too Much Weight Too Fast

It is more likely that hair will fall out on Zepbound if you lose weight rapidly, as the body has difficulty adjusting and is more stressed. Avoid this by asking your healthcare provider how to lose weight slowly and steadily.

Consider a Lower Dosage

Consider asking your doctor if a lower dose of Zepbound would be appropriate in your case to reduce the risk of side effects and avoid hair loss.

Address Any Underlying Medical Conditions

Your doctor may exclude other causes of hair loss, some of which are an underactive thyroid or iron deficiency.

Manage Stress Levels

Manage emotional stress with deep breathing, relaxation methods, good quality sleep, and support groups.

Encourage Hair Growth

Gentle Hair Care

Look after your hair and don’t stress the follicles; avoid excessive heat styling, tugging them with tight hairstyles, and irritating them with harsh cleansers and chemical treatments. Instead, use sulfate-free shampoos, hydrating conditioners, and heat protection.

Balanced Diet

Ensure you’re eating a nutrient-rich diet with adequate protein intake before and while taking Zepbound. This is essential for your overall health and might help protect your hair follicles. To help you with this, consider working with a nutritionist.

Supplements for Hair

Ask your doctor if you’d benefit from a specially formulated hair, skin, and nails supplement to support hair regrowth. These are usually readily available over the counter and contain iron, zinc, biotin, and vitamin D.

Scalp-Stimulating Treatment

Prescribed hair loss treatments that may stop hair thinning and promote hair growth might be appropriate in certain circumstances; examples are minoxidil and finasteride, but your doctor will guide you on this.

Scalp Massage

Scalp massage is excellent for scalp health and relieves stress and muscular tension. It increases blood flow and removes hair product buildup and dead skin cells.

Importantly, these suggestions might not work for everybody, and there are situations when you should chat with a doctor.

When to Talk to Your Healthcare Provider

Some signs and symptoms suggest other causes for hair loss or require stopping the Zepbound. You should seek professional help if any of the following occur:

  • Unusual hair loss patterns such as patchiness, one-sided, or circular baldness.
  • Scalp itching, scaling, or redness.
  • Menstrual changes or facial hair growth in females.
  • Severe fatigue.
  • Anxiety that doesn’t ease.
  • Persistent or excessive hair loss.

Every situation is different, and if your healthcare provider decides that the best choice is stopping Zepbound, the good news is that there are other weight loss medications to try.

Conclusion

Although Zepbound causes hair loss in some people, it is temporary, and there are ways to lessen this side effect.

Now that you feel reassured, take the next step towards getting a Zepbound prescription; medical providers at MEDvidi are here to help by answering any more questions you may have and can issue a script online if deemed appropriate, so book your online weight loss consultation today.

Frequently Asked Questions about Zepbound and Hair Loss

Unfortunately, Zepbound does cause hair loss in about 5 out of 100 people who use it. The good news is that it is temporary, and you can minimize the risk by slowing weight loss and keeping hair follicles healthy.

In trials, hair loss occurred in at least 5 out of every 100 people using Zepbound, making it a common side effect.

The main reason you are experiencing hair loss on Zepbound is that it causes rapid weight loss, which stresses the whole body, disrupting the hair growth cycle.

You will know if your hair is falling out from Zepbound when you see more hair than usual in your hairbrush or in the bath or shower after washing your hair, a couple of months after starting the medication. It’s always best to consult your healthcare provider about potential causes.

Hair loss from Zepbound is usually temporary, and hair starts to grow back without any specific treatment after your weight stabilizes or you stop the medication.

Sources

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8 sources
  1. DailyMed - ZEPBOUND- tirzepatide injection, solution ZEPBOUND- tirzepatide injection, solution. Nih.gov. Published 2024.
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  2. HIGHLIGHTS OF PRESCRIBING INFORMATION ZEPBOUND® (tirzepatide) Injection, for subcutaneous use Initial U.S. Approval: 2022
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  3. Murphrey MB, Agarwal S, Zito PM. Anatomy, Hair. [Updated 2023 Aug 14]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan
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  4. Bryant E. How stress causes hair loss. National Institutes of Health (NIH). Published April 12, 2021.
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  5. Chen H, Liu C, Cui S, et al. Intermittent fasting triggers interorgan communication to suppress hair follicle regeneration.
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  6. Rinaldi F, Trink A, Mondadori G, Giuliani G, Pinto D. The Menopausal Transition: Is the Hair Follicle
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  7. Desai DD, Sikora M, Ambika Nohria, et al. GLP‐1 agonists and hair loss: a call for further investigation. International Journal of Dermatology. Published online May 13, 2024.
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  8. Hair Problems.
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Dorianne Green
Written by:
Dorianne Green
Medical Writer
Dr. Michael Chichak
Medical Reviewer:
Dr. Michael Chichak
MD
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