Saxenda (liraglutide) and Wegovy (semaglutide) are two medications that have gained attention for their potential to aid body weight loss. Although they proved to provide clinically significant effects, it’s essential to understand how these medications work and their suitability for different individuals. In this blog post, we’ll compare Saxenda and Wegovy as weight loss medications, exploring their differences and considerations for those considering them for weight management.
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What Are Wegovy and Saxenda Prescribed For?
These medications are prescribed for individuals who meet body mass index (BMI) criteria. For those with a BMI of 30 kg/m² or higher, medications like Wegovy or Saxenda may be considered to address obesity-related health risks. If individuals have at least one weight-related condition, such as hypertension, type 2 diabetes, or dyslipidemia, and a BMI between 27 and 29.9 kg/m², they may be prescribed one of these medications as well.
Both Wegovy and Saxenda are subcutaneous injectable medications. They are available as pre-filled pens which deliver doses predetermined into the body.
Are Wegovy and Saxenda the Same?
Wegovy and Saxenda share similarities as medications indicated for chronic weight management. Both belong to the class of glucagon-like peptide-1 (GLP-1) receptor agonists and exhibit a similar
Both Saxenda and Wegovy also slow down stomach emptying, promoting a sense of fullness, ultimately reducing overall food intake. Activation of GLP-1 receptors in the central nervous system is essential for appetite regulation, resulting in a reduced sense of hunger and increased satiety. The combination of the above-mentioned mechanisms collectively results in body weight loss.
Differences Between Saxenda and Wegovy
While Wegovy and Saxenda have similarities, they still have several differences. Some of them are discussed in the table below.
| CATEGORY | SAXENDA | WEGOVY |
| Active ingredient | Liraglutide | Semaglutide |
| Effectiveness | Clinical studies have indicated that Wegovy may be slightly more effective in promoting weight loss compared to Saxenda. | The higher dosage of semaglutide used in Wegovy trials has demonstrated a |
| Dosing schedules | Once-weekly injections of 2.4 mg. | Once-weekly injections of 0.25 mg. |
| Side effects and safety | Nausea, vomiting, diarrhea, abdominal pain, dizziness, palpitations and constipation. Generally favorable safety. | Nausea, vomiting, diarrhea, loss of appetite, headache, and constipation. Generally favorable safety but comparatively |
Who Should Avoid Saxenda or Wegovy
Although Saxenda (liraglutide) and Wegovy (semaglutide) are approved for weight management, there are certain individuals who should avoid using them due to potential risks and contraindications. These include the following:
- Individuals with a history of allergic reactions to liraglutide or semaglutide.
- People with a history or diagnosis of multiple endocrine neoplasia syndrome type 2 (MEN 2).
- Individuals with pancreatitis history.
- Individuals with a personal or family history of medullary thyroid carcinoma (MTC), a type of thyroid cancer.
- Individuals with a history of cardiovascular disease such as high blood pressure, high cholesterol, etc.
- Individuals with a history of gastrointestinal disorders, particularly inflammatory bowel disease (IBD)
- People with severe renal impairment may need dosage adjustments or may be advised against the use of these medications.
- Pregnant and breastfeeding individuals.
It’s important to inform your healthcare provider of all existing health conditions.
Which Is Better for Weight Loss, Wegovy or Saxenda?
The question of which medication is better for weight loss does not have a one-size-fits-all answer. The choice between Saxenda and Wegovy depends on plenty of factors, including individual health status, current health conditions, individual preferences, and responses to the medications. Wegovy has shown greater weight loss outcomes in clinical trials, but Saxenda still remains a valid and effective option for many individuals.
Side effects and tolerance to them are important factors in choosing medication. Potential contraindications also prominently impact the choice between Saxenda and Wegovy. Certain metabolic health conditions may favor the use of one medication over the other.
If you are considering weight loss medication, it’s crucial to work closely with your healthcare provider to determine the most suitable treatment plan based on your individual needs and health status.
Can You Switch From Saxenda to Wegovy?
Switching from Saxenda to Wegovy or vice versa should only be considered under the guidance of a healthcare professional and based on a Saxenda to Wegovy conversion chart. Various factors such as individual response to the current medication, side effects, and overall health status influence your doctor’s decision. It’s crucial to consult with a healthcare provider before making any changes to the prescribed treatment plan. Self-initiating a switch without professional guidance is not recommended.
Can Saxenda and Wegovy Be Used Together?
Combining Saxenda (liraglutide) and Wegovy (semaglutide) is not recommended because it’s not considered safe. They are typically prescribed independently based on individual patient circumstances.
Since both Wegovy and Saxenda are GLP-1 receptor agonists, combining them may increase the risk of side effects, mainly gastrointestinal issues such as nausea, vomiting, and diarrhea. Always consult your healthcare provider if you have any questions or concerns about your weight management plan.
Conclusion
In the pursuit of effective weight management, both Saxenda and Wegovy are viable options. Whichever of them is prescribed, it should be supplemented with lifestyle modifications, dietary changes, and increased physical activity.
Remember that the decision between the two medications should be made by a healthcare professional who can best assess your health status and needs.
FAQ
Do you lose more weight with Saxenda or Wegovy?
Do Saxenda and Wegovy work the same way?
What is more effective than Saxenda?
The effectiveness of the same weight loss medication may vary from person to person. Alternative medications for weight loss include Orlistat (Xenical), Contrave (naltrexone/bupropion), Qsymia (phentermine/topiramate), and Wegovy (semaglutide). However, the choice is best determined by a healthcare professional depending on various factors such as medical history, potential side effects, and individual response.
What is similar to Saxenda and Wegovy?
There are various other brands of generic liraglutide and semaglutide available. Some of the brands containing the same active ingredients as Saxenda and Wegovy include Victoza and Ozempic respectively. It’s important to note that only a healthcare professional can prescribe and recommend specific treatments based on an individual’s health condition.
