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Can You Take Xanax and Adderall Together?

Dorianne Green
Written by:
Dorianne Green
Medical Writer
Dr. Henry Bradford
Medical Reviewer:
Dr. Henry Bradford
MD
The medications listed on this website are provided for informational purposes only.

Their inclusion does not guarantee they will be prescribed to any individual, as treatment decisions are ultimately at the discretion of healthcare providers. Healthcare providers may prescribe other medications or recommend non-pharmacological treatment based on the patient’s unique health circumstances and needs. Read more

Both Xanax [1*] and Adderall [2*] have a boxed warning, the most serious type of warning from the Food and Drug Administration (FDA). The active ingredients of these medications carry a risk of abuse, misuse, and addiction, among other potential dangerous effects. Xanax and Adderall are controlled substances (Schedule IV and Schedule II, respectively); specific federal and state laws limit the amount of these medications that can be prescribed or dispensed within a certain period of time.

Highlights

  • Xanax is a prescription medication used for treating certain anxiety disorders.
  • Adderall is commonly prescribed for the treatment of attention deficit hyperactivity disorder (ADHD).
  • Anxiety and ADHD often co-exist, and Xanax and Adderall might be prescribed together but it is not commonly recommended and requires a doctor’s supervision. 
  • Mixing Adderall and Xanax can result in an increased risk of overdose and addiction.

You have likely heard of two medications, Xanax (alprazolam) and Adderall (amphetamine/dextroamphetamine), when talking to colleagues or friends, or online; they sound like ‘serious’ medications not to be taken lightly. You might also have been taking one of them, and you’re wondering if it is safe to use them together. 

By the end of this article, you will have your answers.

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What Is Xanax?

Xanax is a benzodiazepine prescription medication used to treat anxiety disorders because of its calming effect on brain activity. It does this by enhancing the action of the ‘relaxation’ chemical GABA (gamma aminobutyric acid).

What Is Adderall?

Adderall [3*] is a commonly prescribed medication for treating attention deficit hyperactivity disorder (ADHD). It falls into the class of stimulants, and can be used from the age of 6 years. 

It works in the central nervous system [4*] (brain and spinal cord) by increasing chemical messenger concentration (norepinephrine and dopamine) between the nerves, enhancing focus and attention, and providing increased energy.

"ADHD and anxiety frequently co-occur. When core ADHD symptoms — such as inattention or hyperactivity — interfere with daily functioning, whether in school, work, or relationships, it can be both stressful and emotionally distressing. This ongoing struggle to meet personal expectations or responsibilities may contribute to the development of anxiety and/or depressive symptoms."
Dr. Henry Bradford, MD
Medical provider at MEDvidi

Key Differences: Xanax vs Adderall

 

Xanax

Adderall

Generic Name

Alprazolam

Amphetamine + dextroamphetamine sulfate

Drug Class

Benzodiazepine

Stimulant

Approved Uses

Specific anxiety disorders:

  • Generalized anxiety disorder
  • Panic disorder
  • ADHD
  • Narcolepsy

Effects

  • Calming effect
  • A ‘downer’ 
  • Stimulating effects
  • An ‘upper’

As you can see, they have opposite effects on the brain and body, so how do they interact?

Interaction Between Adderall and Xanax

If you check for Xanax and Adderall drug interactions online, for example, on Medscape or WebMD [5*] , you will see that they report that if used together:

  • A significant interaction is possible
  • Monitoring by a doctor is required

So, it is not common to take them together, and if someone needs the combination, medical supervision is a must.

Consult a healthcare provider to learn what treatment plan for ADHD or anxiety can be the most suitable for you.

When Can You Take Adderall and Xanax Together?

Despite the Adderall and Xanax interactions, you can take them together if they are prescribed by the same healthcare professional — although it is a rare situation, and alternative approaches are typically considered.

Believe it or not, 1 in 4 [6*] ADHD patients have co-existing anxiety, and it follows that in some cases, Xanax and Adderall might be an appropriate combination. However, for most people, other alternatives will be prescribed as part of a personalized treatment plan, taking the symptoms and their severity into account.

If these two medications are prescribed together, it is important to follow the prescribed dosage and timing to avoid unnecessary risk.

But why is there a risk? If one is a downer and the other an upper, shouldn’t their potential side effects be ‘canceled out’?

Let’s look closer at the importance of strict medical supervision to balance the effects safely.

"We generally avoid prescribing stimulants (e.g., Adderall) and benzodiazepines (e.g., Xanax) concurrently, as this combination can contribute to a problematic cycle. Stimulants may exacerbate anxiety and disrupt sleep, increasing reliance on benzodiazepines. In turn, depressant medications can cause cognitive blunting or fatigue, potentially driving further use of stimulants. When one class of medication is necessary — for treating ADHD or an anxiety disorder — we typically explore alternative, less habit-forming options to manage any co-occurring symptoms."
Dr. Henry Bradford, MD
Medical provider at MEDvidi

Dangers of Combining Adderall and Xanax

Because of their opposing effects, combining Xanax with Adderall can be a dangerous practice, leading to serious risks of addiction, abuse, and overdose. Let’s look at why this happens.

Increased Risk of Addiction

Both Adderall and Xanax are controlled substances and have a boxed warning; even if you are only taking one of these medications, you have a risk of substance abuse, misuse, and addiction [7*] . The Adderall and Xanax combination increases this risk.

Decreased Effectiveness of Both Drugs

Even when used alone at prescribed doses, Adderall can potentially have serious effects. Now, adding Xanax masks [8*] the ‘upper’ or stimulant effects of Adderall, and there is a risk that people may need more Adderall to feel the same effect, which may have life-threatening consequences. 

The opposite is true for individuals who are only taking Xanax for anxiety. When they take Adderall, their anxiety might spike; they need more Xanax to get the ‘downer’ or calming effect, leading to a higher risk of deadly adverse reactions and overdose.

This decreased effectiveness of one medication and the need for more of the other increases the risk of addiction further.

Never exceed the prescribed dosage and avoid combining medications without consulting with your healthcare provider first to avoid dangerous health consequences.

Recognizing Misuse and Addiction

Misuse means using a medication when it wasn’t prescribed for you. In other words, if you consider the misuse of Adderall, young adults may take it to help them concentrate or stay awake while studying. In 2017, about 6 out of 100 US high school seniors [7*] reported misusing Adderall.

Misusing Xanax might happen when someone who has a sleep disorder takes a few tablets from their friend who was prescribed Xanax for their panic attacks.

Doctors screen people’s history and co-existing medical conditions to ensure safe medication use before prescribing it.

Taking any medication not prescribed for you is dangerous. Avoid self-medication.

Misuse of either medication can also lead to [7*] physical dependence, which means the brain and body need the medication to function; when it is stopped suddenly, the symptoms of dependence appear as a nasty physical withdrawal. Note that benzodiazepine withdrawal after long-term use can be life-threatening whereas stimulant withdrawal is not as severe.

Withdrawal symptoms can include:

  • Shaking
  • Sweating
  • Headaches
  • Seizures symptoms
  • Mood swings
  • Feeling spaced out 
  • Problems sleeping or sleeping too much
  • Depression

Drug dependence is connected with addiction. It can start with tolerance, which is needing an increased dose for the same effect over time. It then can progress to dependence, a psychological and physical requirement for continuous use of the medication to feel normal (or functional). Finally, it can develop into addiction. Importantly, the warning signs of addiction [7*] are obsessively looking for the next dose and taking more of the drug, even if it has negative effects.

Signs and Symptoms of Adderall Abuse and Overdose

Because Adderall is an ‘upper’, it causes a spike in the body functions, causing:

  • Severe anxiety
  • Hallucinations
  • Aggression
  • Abnormal heart rhythms
  • Heart failure
  • High blood pressure
  • High heart rate
  • Strokes and heart attacks
  • Seizures

Signs and Symptoms of Xanax Abuse and Overdose

The key signs of Xanax abuse and overdose [9*] include extreme sedation, cognitive impairment, and slurred speech. Fatigue, nausea, and irritability are a few other symptoms.

Because Xanax is a ‘downer’, it causes a drop in the body functions, causing extreme side effects which can be life-threatening:

  • Severe sedation
  • Respiratory depression (slow and shallow breathing)
  • Confusion
  • Dizziness and falls
  • Slurred speech
  • Low heart rate
  • Low blood pressure

Dependence and Addiction Treatment and Recovery

Addiction recovery focuses on reducing doses of the medication until the person no longer craves and seeks it, and can be done in a hospital or as an outpatient.

Xanax addiction treatment is a long process and needs to be supervised by a doctor. Because of the potential dangers of withdrawal symptoms, the dose must be dropped exceptionally slowly, since the brain and body need the benzodiazepine to function. Adderall detox also requires a tapering-off strategy along with counseling or therapy.

Using Adderall with Xanax sounds terrifying, so what other options are there?

Possible Alternatives to Address ADHD and Anxiety

If Adderall is making anxiety disorder worse, there are alternatives; your doctor may recommend using non-stimulant ADHD medications, which have fewer side effects.

Xanax is usually not a first-line medication for anxiety because of the potential for addiction. It is more likely that your healthcare provider will start you on antidepressants, such as selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs). These medications are less likely to mask the stimulant effect of Adderall.

Also, other non-medication options exist, such as holistic therapies (mindfulness meditation and yoga) and talk therapy.

Summing Up

Summing it up, it is generally not recommended to take Adderall and Xanax simultaneously for chronic use; see your medical provider for a consultation to determine the most appropriate treatment for you.

Proper medical guidance is vital when being treated for ADHD or anxiety. If you believe that you may benefit from a Xanax trial or an Adderall prescription, book an appointment to find out about online ADHD treatment.

FAQs

No, Adderall is not a benzodiazepine; it is a stimulant medication prescribed for attention deficit hyperactivity disorder (ADHD).

Yes, you can take anxiety medication with Adderall as long as your doctor prescribes it. Sometimes it is necessary, as anxiety disorders and ADHD frequently co-exist.

Yes, you can take ADHD and anxiety medication at the same time as long as your doctor prescribes it. 1 in 4 [6*] ADHD patients also have anxiety.

If you take Xanax and have ADHD, it may cause you to lose focus and feel tired because of its calming and sedating effects.

You must consult your doctor if you are unsure of how to take Adderall and Xanax; you should never mix these medications unless prescribed for you by a healthcare professional who is aware that you are taking them both.

Only take Adderall and Xanax on the same day if your doctor has recommended it; never accept medication from anyone if it was not prescribed for you.

Sources

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9 sources
  1. DailyMed - ALPRAZOLAM tablet. Nih.gov. Published 2024.
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  2. DailyMed - ADDERALL- dextroamphetamine saccharate, amphetamine aspartate, dextroamphetamine sulfate, and amphetamine sulfate tablet. Nih.gov. Published 2024.
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  3. HIGHLIGHTS of PRESCRIBING INFORMATION. ADDERALL XR
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  4. Sharbaf Shoar N, Marwaha R, Molla M. Dextroamphetamine-Amphetamine. [Updated 2023 May 23]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
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  5. Evan Starkman. Drug Interaction Checker – Check for Interactions Between Prescription Medications. WebMD. Published 2019.
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  6. D'Agati, E., Curatolo, P., & Mazzone, L. (2019). Comorbidity between ADHD and anxiety disorders across the lifespan. International Journal of Psychiatry in Clinical Practice, 23(4), 238–244.
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  7. Misuse of Prescription Drugs.
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  8. Rush, Craig R. PhD; Stoops, William W. MA; Wagner, Frances P. RN; Hays, Lon R. MD; Glaser, Paul E.A. MD, PhD. Alprazolam Attenuates the Behavioral Effects of d-Amphetamine in Humans. Journal of Clinical Psychopharmacology 24(4):p 410-420, August 2004.
    Source link
  9. Bounds CG, Patel P. Benzodiazepines. [Updated 2024 Jan 30]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
    Source link
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Dorianne Green
Written by:
Dorianne Green
Medical Writer
Dr. Henry Bradford
Medical Reviewer:
Dr. Henry Bradford
MD
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