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Natural Antidepressants: Foods That Help With Depression

Dorianne Green
Written by:
Dorianne Green
Medical Writer
Dr. Henry Bradford
Medical Reviewer:
Dr. Henry Bradford
MD

Highlights

  • There is a strong link between diet and depression, and understanding nutrition is essential for patients with major depressive disorder.
  • Foods that can help depression (in order of their Antidepressant Food Score (AFS) ranking) are vegetables, fruits, seafood, legumes, meats, grains, nuts and seeds, and dairy.
  • Eating a Mediterranean diet, which focuses on most of these food groups, is associated with lower risks of depression.

You’ve been feeling sad and physically, mentally, and emotionally flat for months; you suspect that you might have major depressive disorder (MDD), and you’re trying to work out the next steps. However, you’ve heard you might be able to decrease depressive symptoms naturally with diet.

And you are correct. What we eat matters for every aspect of our health, including our mental health; in fact, this has inspired an entire branch of medicine known as nutritional psychiatry[1] . So, while professional help is essential if you think you have MDD, it’s beneficial to know what foods can help with depression too.

Noticing persistent sadness? Schedule a time to talk to a healthcare provider online.

Link Between Diet and Depression

Good mental health relies on tiptop brain health, which in turn requires balanced nutrition.

Think of it like this: flour, butter, eggs, salt, and baking soda are needed to bake a good cake. In the same way, complex carbohydrates, protein and amino acids, antioxidants, selenium, vitamin D, omega-3 fatty acids, water, vitamin Bs, and zinc are essential in the ‘brain health recipe’.

In the cake recipe, if you leave out or skimp on ingredients, say you swap butter for oil, or forget the eggs, your cake still bakes, but it comes out flat, hard, or dry. In the same way, a poor diet starves the brain of its essential ‘recipe’ items, and instead of a light, fluffy mood, it flops; the result may be low energy, foggy thinking, and depressive symptoms.

But this can be reversed and improved by trying again with the correct ingredients; a study showed that adding a healthy diet for three months to the treatment of patients with depression improved their moods.

If you’re experiencing suicidal or self-harming thoughts and require immediate assistance, contact a crisis hotline, such as 911, 988 suicide & crisis lifeline (toll-free), or Samaritans (116-123 or via chat).

Essential Nutrients for Brain and Mood

Next, we’ll look at each brain-and-mood-health ingredient and their role in the ‘recipe’ more closely.

Protein and Amino Acids

Protein boosts logical thinking, decision-making, and memory, and is a vital part of your diet.

Protein, a macronutrient, provides essential amino acids[2] , which are building blocks for:

  • Enzymes that trigger chemical reactions in the brain. 
  • Hormones.

One of these essential amino acids is tryptophan[3] , which forms the feel-good hormone and neurotransmitter serotonin.

Complex Carbohydrates

Back to basics: carbohydrates are a type of macronutrient made up of sugars that provide the brain with energy. Importantly, when sugar enters the brain, so does tryptophan[4] .

Carbohydrates can be simple or complex. A complex carbohydrate has a complicated three or more sugars[5] structure. It makes sense then that breaking down a complex carbohydrate takes longer, releasing glucose slowly and consistently, preventing sugar rushes and crashes.

Therefore, by eating complex carbohydrates, the brain has a steady supply of energy, allowing thinking and memory to improve; also, the brain ages better. When function and coping is at peak, depression risk may be lower.

Nutrient Antioxidants

An antioxidant[6] is a molecule that helps to prevent cell damage to proteins and DNA. This is a very broad term, and common dietary antioxidants[7] include vitamins C and E, beta-carotene, selenium, and plant compounds, such as flavonoids and polyphenols.

Selenium

Selenium is a mineral that acts as an antioxidant[8] , and low levels are associated with depression[4] . It supports many body systems, for example, the immune system and thyroid hormone production[8] . Depression and anxiety are common symptoms of an underactive thyroid.

Omega-3 Fatty Acids

Long-chain omega-3 fatty acids, such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are essential for brain health; they work by:

  • Directly affecting nerve structure
  • Enhancing neurotransmitter release
  • Protecting against cell damage

Also, depression is linked to[4] omega-3 fatty acid deficiency. Unfortunately, the only food that provides high levels of EPA and DHA is oily fish, so many people take supplements.

Water

About 70% of your body weight is water, and most of that is in the cells. It makes sense that you need to replenish this water for the body and the brain to work at peak. One study using MRI images shows that dehydration negatively impacts brain structure, and that both gray and white matter improve after consuming water.

Vitamin Bs

B vitamins play a vital role in nerve and brain health. The easiest way to understand this is to look at the symptoms of deficiencies[9] :

  • Thiamine (B1) — confusion, memory loss, and being off balance
  • Niacin (B3) — dementia
  • Pyridoxine (B6) — confusion and seizures
  • Biotin (B7) — depression
  • Folate (B9) — depression[4]
  • Cobalamin[10] (B12) — depression, difficulty thinking, making decisions, and memory loss

Zinc

Zinc is an essential micronutrient in the brain[11] that helps with the growth and regulation of nerves, as well as the communication between them. A deficiency affects learning, thinking, and memory, and the levels are often low[4] in patients with depression.

Vitamin D

Vitamin D deficiency can cause depression, poor memory, and insomnia. 

Interestingly, vitamin D receptors[12] are found in the brain’s depression-related areas, where it:

  • Has an anti-inflammatory[12] effect, improving functioning.
  • Keeps serotonin, dopamine, and noradrenaline levels topped up[13] , lifting mood.

It’s called the sunshine vitamin for a reason; sun-exposed skin usually provides 90% of the body’s vitamin D needs, and, unfortunately, there are few dietary sources[14] . This means that despite a vitamin D-focused diet, you should spend time outdoors, monitor your blood levels, and ask your doctor’s advice on supplements.

Traditional medicine often overlooks the important role of diet and nutrition in mental health. Meeting the body’s nutritional needs can help manage symptoms of anxiety and depression, sometimes on its own, and, in other cases, alongside more robust treatment strategies which may include therapy or medication management.
Dr. Henry Bradford, MD
Medical provider at MEDvidi

Why Should You Feed Your Bowel Bacteria?

If your gut flora is out of balance, it can lead to depression and mental illness.

Bowel bugs do talk to your brain in a few ways:

  • Along nerves
  • Via hormones: they produce noradrenaline, serotonin, dopamine
  • Through the immune system

This is called the brain-gut-microbiome axis, and it only functions well if your bowel bacteria are healthy, so include food they love in your diet:

  • Prebiotics: Your gut microbiome loves feeding on prebiotic whole, fiber-rich plant-based foods containing fructo-oligosaccharides (FOS), galacto-oligosaccharides (GOS)[15] , and inulin[16]
  • Probiotics: You can also top up your good bowel bacteria with living organisms called probiotics, which are usually in fermented foods or probiotic supplements.
Struggling despite healthy changes? Professional help for depression can make a difference.

Natural Antidepressants: What Foods Help With Depression and Anxiety?

The following table lists good sources for each of these essential nutrients.

Key Nutrients for a Healthy Brain and Good Mood: Food Sources

Nutrient

Food Sources

Complex Carbohydrates

Whole grains (oats, brown rice, quinoa), legumes (lentils, beans), starchy vegetables (sweet potatoes, corn)

Protein and Amino Acids

All nine essential amino acids[2] : meats, seafood, soy products, eggs, dairy

Only certain amino acids[2] : whole grains, nuts, legumes, and seeds

High tryptophan: turkey, chicken, soybeans, chickpeas[17]

Antioxidants

  • Vitamin A: beta-carotene — carrots, sweet potatoes, pumpkin, butternut squash, spinach.
  • Vitamin C: citrus fruits (oranges, lemons), strawberries, kiwi, bell peppers, broccoli.
  • Vitamin E: almonds, sunflower seeds, spinach, avocado, wheat germ.
  • Flavonoids: apples, onions, tea (especially green and black), berries, dark chocolate.
  • Polyphenols: berries, grapes, olive oil, coffee, green tea.

Selenium[8]

Brazil nuts, sunflower seeds, mushrooms, fish, seafood, beef, poultry, eggs, whole grains

Omega-3 Fatty Acids

Fatty fish (salmon, sardines, mackerel), chia seeds, flaxseeds, walnuts

Water

Plain water, herbal teas, water-rich fruits (watermelon, cucumber, oranges)

Vitamin Bs

Whole grains, leafy greens, eggs, dairy, poultry, legumes

Zinc

Oysters, pumpkin seeds, beef, chickpeas, cashews

Vitamin D

Fatty fish (salmon, mackerel), fortified dairy or plant milks, egg yolks, mushrooms exposed to sunlight[18]

Prebiotics

FOS[15] : onions, garlic, tomatoes, bananas, and whole wheat.

GOS[15] : whole wheat, onion, garlic, and legumes.

Inulin[16] : onions, garlic, wheat, Jerusalem artichokes, and bananas.

Probiotics

Yogurt with live cultures, kefir, sauerkraut, kimchi, miso

Other antidepressant nutrients[19] include folate, iron, magnesium, and potassium.

Weight Management as an Antidepressant Strategy

This could be viewed as a chicken-or-egg situation, but also a vicious cycle.

On one hand, obesity increases the risk of depression and anxiety because of inflammation, insulin resistance, type 2 diabetes risk, and high blood pressure; all of these are bad for your brain.

On the other hand, a poor diet consisting of excess saturated fat, processed foods, and sugar, paired with little physical activity, might affect brain function as well as lead to:

  • Gut inflammation that disrupts the gut-brain axis
  • Brain inflammation

All of which can dip mood, motivation, and emotion.

In addition, people with severe depression may neglect their diets, causing the cycle to start.

This motivates the need not only for dietary improvement for weight management, but also for a list of ingredients or foods for depression to form part of the treatment.

10 Best Foods to Eat for Depression

Next, you’re probably wondering what to eat when you’re depressed. You need to understand that these foods are not a quick fix; you should always consult a healthcare professional if you are feeling sad and hopeless for more than two weeks.

With the help of the Antidepressant Food Score (AFS)[19] , here are our top natural antidepressant food recommendations.

1. Antioxidant- and vitamin-rich Vegetables

Vegetables are good foods for depression, with the highest[19] in the AFS; in particular:

  • Leafy greens: spinach, lettuce, and kale
  • Fresh herbs: cilantro, basil, and parsley
  • Cruciferous: cauliflower, broccoli, and brussel sprouts
  • Yellow, red, and orange: peppers, red cabbage, pumpkin, and butternut squash

2. Oysters, Clams, and Mussels

This might not please many people, but oyster, clams and mussels are the highest-ranking animal[19] foods that fight depression; they are rich in all nine essential amino acids, omega-3 fatty acids, vitamin D, and selenium.

3. Fish

The more commonly consumed higher-ranking ones, according to the AFS, are tuna, rainbow trout, salmon, and herring, but most fatty fish are good sources of all nine essential amino acids, omega-3 fatty acids, vitamin D, and selenium.

4. Fruit

Fruits like strawberries, papaya, and lemons are an essential element of a healthy and nutrient-rich diet and have a high AFS; they are rich in vitamin C, fiber, and antioxidants.

5. Legumes

Beans, lentils, chickpeas, and soy products made it into the AFS ranking; they are full of the good stuff: protein, specific essential amino acids, B vitamins, complex carbohydrates, and fiber.

6. Poultry

Poultry, including chicken, but in particular[20] , turkey, provides tryptophan, an essential amino acid, that helps your body to produce serotonin, making you feel calmer and happier. Meats also contain all the other essential amino acids, as well as selenium and the B vitamins.

7. Whole Grains

These made the AFS list because they contain complex carbohydrates, fiber, some essential amino acids, vitamin Bs, and selenium.

8. Nuts

Nuts are a good source of fiber and healthy fats. Certain nuts are also high in tryptophan, selenium, and zinc, which may help with brain function and reduce your risk of depression.

9. Seeds

Flaxseed and chia seeds are high in Omega-3. In addition, certain seeds are high in zinc and selenium. A lack of these minerals, which are essential for brain function, has been linked to higher rates of depression.

10. Caffeine

Yes, you read correctly, coffee consumption may be good for you. A study showed that consuming caffeine in low doses[21] may help reduce depressive symptoms. However, note that it may cause or worsen symptoms of anxiety in people sensitive to caffeine.

Want to go beyond diet and get personalized support for your mood? Book an online visit today.

Tips to Make This Easier

Get a Mediterranean Cookbook

The Mediterranean diet, rich in fish, vegetables, olive oil, legumes, and nuts, is an easy way to eat antidepressant foods.

Eat Mood-friendly Snacks

Keep nuts, seeds, and fruit on hand instead of reaching for crisps and sweets.

"With so many nutrition plans claiming to be the best, it can be hard to know where to start. A simple, practical approach is to focus on a balanced variety of whole foods, opting to prepare meals at home rather than relying on restaurants or take-out, and limiting processed foods — principles that underlie nearly all healthy eating plans."
Dr. Henry Bradford, MD
Medical provider at MEDvidi

Go Whole and Balanced

Try to combine in each meal:

  1. Chicken, turkey, or fish
  2. Two vegetables, one green and one yellow, red, or orange
  3. A complex carb

For example, grilled salmon with quinoa and roasted vegetables drizzled with olive oil.

Choose Energy-Steady Carbs

Swap ready-made breakfast cereals, and white bread and pasta for wholewheat options, oats, brown rice, or barley.

Alternative Omegas

If fish isn’t for you, try walnuts, chia seeds, or flaxseeds for omega-3s.

Keep Your Brain Hydrated

Make it a habit to drink a glass of water or a cup of herbal tea:

  • When you wake
  • Before each meal
  • Mid-morning with a snack
  • Mid-afternoon with a snack

Are There Foods to Avoid in Depression?

This discussion wouldn’t be complete if we didn’t tell you what to avoid if you have depression.

  • Alcohol consumption, in particular, heavy drinking, is associated with a higher risk of depression.
  • Although it’s tasty and saves time, junk food, sugary drinks, processed meats, and food high in saturated fat increase depression risk[22] ; avoid or limit them!

Summing It Up

Although lifestyle changes, such as increasing physical activity and eating a balanced diet rich in antidepressant foods, should be the base of your approach to feeling better, these are usually not enough for treating depression; medications and psychotherapy are vital in most cases.

If you are looking for online mental health care, contact MEDvidi. Sign up to have an appointment in 24 hours and see a healthcare provider experienced in diagnosing and treating depression online.

Frequently Asked Questions

There are no foods that will instantly make you feel happy; however, you can optimize your diet to contain foods rich in nutrients that support your brain and lower depression risk.

Water is the best drink for depression; it keeps your brain hydrated and functioning well. If you don’t like drinking water, try herbal teas, or eat fruit and vegetables with a high water content, such as cucumber, oranges, and watermelon.
Foods that may help with depression, in this order, are vegetables, fruits, seafood, legumes, meats, grains, nuts and seeds, and dairy. A great way to get the balance is with a Mediterranean diet.
According to the Antidepressant Food Score (AFS), the highest-scoring plant foods were leafy greens, lettuces, and peppers, and animal foods included oysters and mussels, and other seafoods.
Foods that contain high levels of tryptophan, an essential amino acid, are likely to boost serotonin; some examples include turkey, chicken, soybeans, and chickpeas.

Sources

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22 sources
  1. Adan RAH, van der Beek EM, Buitelaar JK, Cryan JF, Hebebrand J, Higgs S, Schellekens H, Dickson SL. Nutritional psychiatry: Towards improving mental health by what you eat. Eur Neuropsychopharmacol. 2019 Dec;29(12):1321-1332. doi: 10.1016/j.euroneuro.2019.10.011. Epub 2019 Nov 14. PMID: 31735529.
    Source link
  2. LaPelusa A, Kaushik R. Physiology, Proteins. [Updated 2022 Nov 14]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
    Source link
  3. Bamalan OA, Moore MJ, Al Khalili Y. Physiology, Serotonin. [Updated 2023 Jul 30]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
    Source link
  4. Rao TS, Asha MR, Ramesh BN, Rao KS. Understanding nutrition, depression and mental illnesses. Indian J Psychiatry. 2008 Apr;50(2):77-82. doi: 10.4103/0019-5545.42391. PMID: 19742217; PMCID: PMC2738337.
    Source link
  5. Holesh JE, Aslam S, Martin A. Physiology, Carbohydrates. [Updated 2023 May 12]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
    Source link
  6. Stone WL, Pham T, Mohiuddin SS. Biochemistry, Antioxidants. [Updated 2023 May 1]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
    Source link
  7. Catoni C, Peters A, Martin Schaefer H. Life history trade-offs are influenced by the diversity, availability and interactions of dietary antioxidants. Animal Behaviour. 2008;76(4):1107-1119.
    Source link
  8. Nessel TA, Gupta V. Selenium. [Updated 2023 Apr 3]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
    Source link
  9. Lykstad J, Sharma S. Biochemistry, Water Soluble Vitamins. [Updated 2023 Mar 6]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
    Source link
  10. Skerrett PJ. Vitamin B12 deficiency can be sneaky, harmful. Harvard Health Blog. Published February 11, 2019.
    Source link
  11. Choi S, Hong DK, Choi BY, Suh SW. Zinc in the Brain: Friend or Foe? Int J Mol Sci. 2020 Nov 25;21(23):8941. doi: 10.3390/ijms21238941. PMID: 33255662; PMCID: PMC7728061.
    Source link
  12. Akpınar Ş, Karadağ MG. Is Vitamin D Important in Anxiety or Depression? What Is the Truth? Current Nutrition Reports. 2022;11(4).
    Source link
  13. Eyles DW. Vitamin D: Brain and Behavior. JBMR Plus. 2020;5(1).
    Source link
  14. Chauhan K, Shahrokhi M, Huecker MR. Vitamin D. [Updated 2023 Apr 9]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
    Source link
  15. Chen G, Li C, Chen K. Fructooligosaccharides. Studies in natural products chemistry. Published online January 1, 2016:209-229.
    Source link
  16. Prebiotics. Elsevier eBooks. Published online October 23, 2015:905-906.
    Source link
  17. Comai S, Bertazzo A, Bailoni L, Zancato M, Costa CVL, Allegri G. Protein and non-protein (free and protein-bound) tryptophan in legume seeds. Food Chemistry. 2007;103(2):657-661.
    Source link
  18. Cardwell G, Bornman JF, James AP, Black LJ. A Review of Mushrooms as a Potential Source of Dietary Vitamin D. Nutrients. 2018 Oct 13;10(10):1498. doi: 10.3390/nu10101498. PMID: 30322118; PMCID: PMC6213178.
    Source link
  19. LaChance LR, Ramsey D. Antidepressant foods: An evidence-based nutrient profiling system for depression. World J Psychiatry. 2018 Sep 20;8(3):97-104. doi: 10.5498/wjp.v8.i3.97. PMID: 30254980; PMCID: PMC6147775.
    Source link
  20. Richard DM, Dawes MA, Mathias CW, Acheson A, Hill-Kapturczak N, Dougherty DM. L-Tryptophan: Basic Metabolic Functions, Behavioral Research and Therapeutic Indications. Int J Tryptophan Res. 2009 Mar 23;2:45-60. doi: 10.4137/ijtr.s2129. PMID: 20651948; PMCID: PMC2908021.
    Source link
  21. Liu QS, Deng R, Fan Y, Li K, Meng F, Li X, Liu R. Low dose of caffeine enhances the efficacy of antidepressants in major depressive disorder and the underlying neural substrates. Mol Nutr Food Res. 2017 Aug;61(8). doi: 10.1002/mnfr.201600910. Epub 2017 May 8. PMID: 28054436.
    Source link
  22. Ejtahed HS, Mardi P, Hejrani B, Mahdavi FS, Ghoreshi B, Gohari K, Heidari-Beni M, Qorbani M. Association between junk food consumption and mental health problems in adults: a systematic review and meta-analysis. BMC Psychiatry. 2024 Jun 12;24(1):438. doi: 10.1186/s12888-024-05889-8. PMID: 38867156; PMCID: PMC11167869.
    Source link
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Dorianne Green
Written by:
Dorianne Green
Medical Writer
Dr. Henry Bradford
Medical Reviewer:
Dr. Henry Bradford
MD
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