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Focalin Versus Concerta: A Side-by-Side Comparison

Written by:
Rabia Khaliq
MSc in Applied Psychology
Reviewer:
Dr. Bradley Noon
MD
Medical Disclaimer
The medications listed on this website are provided for informational purposes only. Their inclusion does not guarantee that they will be prescribed to any individual, as treatment decisions are ultimately at the discretion of healthcare providers. This list is not exhaustive, and healthcare providers may prescribe other medications, including non-stimulant options, based on the patient’s unique health circumstances and needs. Read more

Highlights

  • Both Focalin and Concerta are approved for ADHD treatment.
  • They elevate the levels of dopamine and norepinephrine in the brain.
  • They have different chemical compositions, available dosages and forms, the onset and duration of action, and potency.
  • Headaches, dry mouth, decreased appetite, weight loss, stomach issues, anxiety, and lack of sleep are a few common side effects.

Attention deficit hyperactivity disorder (ADHD) affects about 4.4% [1*] of adults in the US. Varied treatment options for ADHD, including several medications, make it possible to tailor treatment plans to the needs of different patients.

In this article, we provide a detailed comparison of Focalin and Concerta. Both medications are approved to treat ADHD, but they differ in chemical components, available forms and dosages, onset and duration of action, and potency. Read on to better understand their therapeutic mechanisms and possible side effects.

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What Is Concerta?

Concerta [2*] (methylphenidate) is a central nervous system (CNS) stimulant indicated for ADHD treatment. Depending on the condition, methylphenidate can be administered orally in its hydrochloride form or applied to the skin. It is mainly sold under the brand names Ritalin and Concerta. These medications can make you feel active and energized, which helps manage the symptoms of ADHD. It’s necessary to consult a healthcare professional and exercise caution while using them because of the high potential for addiction.

What Is Focalin?

Focalin [3*] (dexmethylphenidate) is also a CNS stimulant medication administered orally to manage ADHD symptoms, like inattention or impulsivity. It is a more potent isomer [4*] of methylphenidate and is equally effective in addressing the symptoms at lower doses. Dexmethylphenidate is sold mainly under the brand names Focalin and Focalin XR, with the latter one being an extended-release medication.

How Do They Work?

As stimulant medications, both Concerta and Focalin aid people with ADHD in becoming more focused, attentive, and able to control their impulses. However, they function differently.

Focalin is believed to work by increasing the levels of specific neurotransmitters in the brain, mainly dopamine and norepinephrine. As a result, it decreases inattention and impulsivity in patients with ADHD.

Concerta also increases dopamine and noradrenaline levels in the brain. It provides a calming effect and helps improve concentration, which makes it one of the most popular medications for ADHD treatment.

Do Focalin and Concerta Reduce Anxiety?

Anxiety and ADHD frequently coexist [5*] . In this case, treatment becomes more difficult because the two conditions might affect one another. For example, anxiety can exacerbate impulsivity and inattention. On the other hand, stimulant medications that are commonly used to treat ADHD can increase anxiety as a side effect.

Neither Focalin nor Concerta are prescribed for anxiety disorders. They can help reduce ADHD symptoms, but if you also have anxiety, your healthcare provider will determine a comprehensive course of treatment to address both conditions.

Consult with medical experts specializing in ADHD and anxiety treatment.

Common Side Effects

Like any other medications, Concerta and Focalin have several side effects. Potential ones are listed below.

Focalin

Concerta

  • Nervousness
  • Restlessness
  • Headache
  • Difficulty falling asleep (insomnia)
  • Upset stomach
  • Lack of appetite
  • Sore throat
  • Dry mouth
  • Headache
  • Anxiety
  • Dizziness
  • Irritability
  • Stomach ache
  • Skin rash
  • Numbness in the hands or feet
  • Dry mouth
  • Nausea
  • Vomiting
  • Weight loss
  • Visual issues
  • Perspiration

If you experience any adverse reactions that are severe, prolonged or disrupt your daily life in another way, gain medical attention as soon as possible to adjust your treatment.

Similarities of Focalin and Concerta

These medicines are similar in many ways, such as:

  • Both are stimulant medications and belong to the same drug class—CNS stimulants.
  • They are classified as Schedule II drugs under the DEA classification, which reflects their high risk of abuse and dependence.
  • They are available only as oral prescription medications on the recommendation of licensed healthcare professionals.
  • They are FDA-approved only for ADHD treatment.
  • Their therapeutic effects are based on increasing the levels of dopamine and norepinephrine in the brain.
  • They are almost equally effective in managing ADHD, excluding individual response variations.
  • Some of their most common side effects include headaches, dry mouth, decreased appetite, weight loss, stomach problems, anxiety, and insomnia.
  • Some of their more severe complications include an increased risk of serious cardiovascular events, abrupt increases in blood pressure and heart rate, psychiatric problems, seizures, detrimental effects on blood vessels, visual disturbances, painful and prolonged erections (priapism), and risk of abuse and addiction.
  • They can be used during pregnancy and lactation but only in cases determined by doctors where the benefits outweigh the risks of the medication.

Differences Between Focalin and Concerta

Besides many similarities, a few key differences do exist between these medications.

Characteristic

Focalin

Concerta

Active ingredient

Dexmethylphenidate hydrochloride

Methylphenidate hydrochloride

Inert ingredients

  • Gelatin
  • Sugar spheres
  • Polyethylene glycol
  • Diethyl citrate
  • Ammonio methacrylate
  • Titanium dioxide
  • Yellow iron oxide
  • Sodium chloride
  • Sunnic acid
  • Butylated hydroxytoluene
  • Hypromellose
  • Synthetic iron oxides
  • Carnauba wax

Available forms

  • Immediate-release tablets (Focalin)
  • Extended-release capsules (Focalin XR)
  • Extended-release tablets

Available strengths

  • 2.5 mg, 5 mg, 10 mg (Focalin)
  • 5 mg, 10 mg, 15 mg, 20 mg, 25 mg, 30 mg, 35 mg, and 40 mg (Focalin XR)

18 mg, 27 mg, 36 mg, and 54 mg

Dosage frequency

  • Multiple daily dosing (Focalin)
  • Once daily dosing (Focalin XR)

Once daily dosing

Potency

2x

1x

Onset of action

  • 30 to 60 minutes (Focalin)
  • 1-2 hours (Focalin XR)

1-2 hours

Duration of action

  • 4-6 hours (Focalin)
  • 8-12 hours (Focalin XR)

8-12 hours

Absolute contraindications

  • Known allergy
  • Combined use with monoamine oxidase inhibitors (MAOIs)
  • Known allergy
  • Combined use with monoamine oxidase inhibitors (MAOIs)
  • Severe anxiety or agitation
  • Tics or Tourette syndrome
  • Glaucoma (raised eye pressure)

Clinically important drug interactions

  • MAOIs
  • Blood pressure medications
  • Halogenated anesthetics
  • Risperidone
  • MAOIs
  • Selective serotonin reuptake inhibitors (SSRIs)
  • Tricyclic antidepressants
  • Vasopressor agents
  • Blood thinner medications
  • Anti-seizure medications
  • Risperidone

Note that dosage frequency, the onset of action, and the duration of effects may vary from one patient to another depending on health specifics and individual response.

Shapes and Colors of Focalin vs Concerta

Immediate-release Focalin tablets are D-shaped and include the following options:

  • D 2.5: 2.5 mg, blue.
  • D 5: 5 mg, yellow.
  • D 10: 10 mg, white.

Focalin XR is available in the form of capsules and has the following colors based on the strengths:

  • 5 mg: light blue
  • 10 mg: light caramel
  • 15 mg: green
  • 20 mg: white
  • 25 mg: light blue and white
  • 30 mg: light caramel and white
  • 35 mg: light blue and light caramel
  • 40 mg: green and white

Concerta pills are elliptical or oval with imprinted “alza” and dosage:

  • Alza 18: 18 mg, yellow.
  • Alza 27: 27 mg, gray.
  • Alza 36: 36 mg, white.
  • Alza 54: 54mg, red.

General Dosage Guidelines

The dosage is determined by the physician and can vary depending on various factors, including age, medical history, side effects, etc. The usual starting dose of Focalin in adults is 2.5 mg twice daily with a maximum dose of 20 mg daily. Concerta’s recommended initial dosage starts at 18 mg or 36 mg per day for adults and can increase to 72 mg daily. These medications should be taken exactly as prescribed, and you should not alter them without consulting your doctor.

Receive comprehensive, personalized recommendations for ADHD treatment at MEDvidi.

The Effectiveness of Focalin vs Concerta for ADHD

Focalin is considered a strong medication compared to Concerta because dexmethylphenidate is stronger than methylphenidate [6*] on a mg-to-mg scale. However, clinically, there is no significant difference between these medications in alleviating the symptoms of ADHD. The only difference lies in dosage determination: dexmethylphenidate-based medications are commonly prescribed at half the dosage of methylphenidate-based medicines. Note that the effectiveness of each medication can differ from one patient to another, and only a healthcare provider can choose the most appropriate course of treatment and adjust it.

How to Obtain a Prescription for Focalin and Concerta

Both medications are Schedule II controlled substances, so they require a prescription from a licensed medical provider. At MEDvidi, you can obtain a prescription based on the following steps: 

  • Symptom assessment: A healthcare provider will evaluate your condition to determine whether Concerta, Focalin, or other medications are appropriate. If further testing is necessary to comprehend your symptoms fully, they will suggest the course of action.
  • Medical history: Be ready to respond to inquiries regarding your past medical experiences and therapies that you may have tried for ADHD management. These include any mental health concerns, previous prescriptions, and current symptoms.
  • Regular supervision: If your healthcare provider prescribes Concerta or Focalin, adhere to dosage guidelines and other instructions. Attend follow-up sessions to monitor your health dynamics and modify your treatment plan if necessary.

If any of these medications appear to be appropriate in your particular case, a MEDvidi provider will write a prescription that will be sent digitally to the pharmacy of your choice.

Summing Up

Although both Focalin and Concerta can help manage ADHD, they differ in chemical components, dosage guidelines, and many other aspects discussed in this article. The choice of medication depends on the intensity of your disorder and individual circumstances. We at MEDvidi are ready to assess your health in detail and offer the most suitable personalized treatment plan for ADHD.

Frequently Asked Questions

These medications can sometimes cause brain fog that causes feelings of cognitive drowsiness and difficulty concentrating. However, not everyone experiences the same side effects.
Switching from Concerta to Focalin or vice versa may cause changes in their bodies’ reactions to the medications. Behavioral changes can include alterations in focus, attention, mood, and sleep patterns.
These medications might differ in price, especially if treatment is needed for an extended period. The dosage, formulation (e.g., brand name vs generic formulations), insurance coverage, and drugstore pricing can all affect the cost.
Switching medications should be done with the guidance of a medical provider. They will monitor your response and suggest a gradual transition or adjust the dosage to optimize your response.

Sources

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6 sources
  1. Attention-Deficit Hyperactivity Disorder
    Source link
  2. Concerta
    Source link
  3. Focalin
    Source link
  4. Attention Deficit-Hyperactivity Disorder
    Source link
  5. Attention deficit hyperactivity disorder and comorbidity: A review of literature
    Source link
  6. Efficacy and safety of extended-release dexmethylphenidate compared with d,l-methylphenidate and placebo in the treatment of children with ADHD: a 12-hour laboratory classroom study
    Source link
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Written by:
Rabia Khaliq
MSc in Applied Psychology
Reviewer:
Dr. Bradley Noon
MD
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This article contains scientific references. The numbers
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