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Strattera for Anxiety: Potential Benefits and Side Effects

Dr. Joanne Nguyen
Author
Dr. Joanne Nguyen
PharmD
Christina Bookwalter
Medical Reviewer
Christina Bookwalter
PharmD
The medications listed on this website are provided for informational purposes only.

Their inclusion does not guarantee they will be prescribed to any individual, as treatment decisions are ultimately at the discretion of healthcare providers. Healthcare providers may prescribe other medications or recommend non-pharmacological treatment based on the patient’s unique health circumstances and needs. Read more

Strattera has a boxed warning[1] , the most serious type of warning from the Food and Drug Administration (FDA). Strattera’s active ingredient, atomoxetine, carries a boxed warning for increased risk of suicidal thoughts and behaviors in children and adolescents with attention-deficit hyperactivity disorder (ADHD). Remember to discuss the risks with your healthcare provider.

Highlights

  • Strattera (atomoxetine) is approved to help treat attention-deficit hyperactivity disorder (ADHD).
  • Strattera may also be used off-label to help treat certain anxiety-related symptoms. However, it is not FDA-approved for anxiety. 
  • Strattera comes with certain side effects and risks. Specifically, it can increase the risk of suicidal thoughts and behaviors in children and adolescents with ADHD.
  • If you are considering medications to treat anxiety-related symptoms, talk with your healthcare provider to learn more about options that are right for you.

Anxiety is the most commonly reported mental health condition among adults in the United States. It is also one of the most commonly diagnosed[2] mental health problems among children. Various treatment options[3] , including cognitive-behavioral therapy (CBT), are effective in managing anxiety. Medications may also help reduce anxiety symptoms and remain one of the first-line treatment options available.

Selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs), such as Zoloft (sertraline) and Cymbalta (duloxetine), are common treatment options for anxiety. However, Strattera (atomoxetine) may also be used off-label to help with certain anxiety-related symptoms, including difficulty concentrating, in some people.

Consult a licensed medical provider online to learn what anxiety treatment can be right for you.

What Is Strattera?

Strattera, also known by its generic name atomoxetine, is approved for the treatment of attention-deficit hyperactivity disorder[1] . It may also help with concentration problems, a reported symptom in people with anxiety.

Unlike some ADHD medications, Strattera hasn’t consistently shown to cause dependence in clinical studies[1] . Because of this, the medication may be a safer option to help with concentration in people at risk of addiction or dependence.

"Strattera is not considered a first-line medication for anxiety, but it may be an option in people who have both anxiety symptoms and ADHD symptoms. Your healthcare provider will evaluate your symptoms and create a treatment plan that is right for you."
Christina Bookwalter, PharmD
Medical writer and reviewer at MEDvidi

Does Strattera Calm You Down?

It’s unknown if Strattera has a calming effect. In clinical studies[1] of Strattera for attention-deficit hyperactivity disorder (ADHD), some people actually reported feelings of anxiety and nervousness.

However, each person responds differently to Strattera, and side effects can vary. So, for others, Strattera may help with certain anxiety-related symptoms, such as difficulty concentrating. Trouble focusing is also a reported problem in people with ADHD[4] , and Strattera has shown to be effective[1] in treating ADHD symptoms. Because of this, Strattera may also help improve concentration in people with anxiety, even though it’s primarily used for ADHD and may be used for anxiety off-label.

An “off-label” use means that the medication is not officially approved to treat that specific condition. The FDA has approved it for treating other conditions, but healthcare providers can prescribe it off-label if it has shown promise through research and clinical use.

How Can Strattera Help With Anxiety-Related Symptoms?

Strattera works by increasing certain chemicals in the brain[5] . These chemicals play a key role in controlling attention. By increasing these brain chemicals, Strattera helps improve your ability to focus, which can be helpful if you have trouble concentrating because of anxiety.

Does Strattera Improve Mood?

It’s unknown if Strattera can directly improve mood; in contrast, feelings of depression and mood swings have been reported[1] by people taking Strattera for ADHD. Strattera also has a boxed warning for increased risk of suicidal thoughts and behaviors in children and adolescents. However, side effects may vary, so it’s important to consult your healthcare provider to determine which treatment is right for you.

What Is the Strattera Dosage for Adults With Anxiety?

Information isn’t available regarding the recommended Strattera dosage for anxiety treatment in adults. This is because Strattera is only approved for ADHD[1] . Whether Strattera is safe and effective for treating anxiety is unknown.

If you are considering Strattera for treating certain anxiety-related symptoms, such as difficulty concentrating, talk with your healthcare provider first. At MEDvidi, you can get help for anxiety online within 24 hours. A licensed healthcare provider will assess your symptoms and determine the most suitable treatment plan to manage your symptoms and condition.

Discuss available treatment options for anxiety and receive a personalized plan online.

Strattera Side Effects

Similar to other medications, Strattera may cause some side effects, whether it’s been prescribed for ADHD or anxiety. These side effects may be mild or serious. The following lists highlight some of the reported side effects, which should be considered before starting Strattera. Note that these lists do not include all possible Strattera side effects. 

Mild Side Effects

Commonly reported[1] mild side effects of Strattera include:

  • Nausea or vomiting
  • Tiredness
  • Appetite changes
  • Stomach pain
  • Constipation
  • Dizziness
  • Dry mouth
  • Sexual side effects

Because Strattera may cause tiredness, it may affect your ability to operate heavy machinery. Be careful to avoid these activities until you know how the medication affects you.

In general, these mild side effects typically improve within days or a few weeks. However, if they are bothersome, don’t go away, or worsen, talk with your provider right away.

Serious Side Effects

Serious side effects reported[1] with Strattera treatment include:

  • Serious liver problems
  • Priapism (a painful and long-lasting penile erection)
  • Problems passing urine
  • Slowed growth (height or weight) in children
  • Serious allergic reactions
  • Heart-related problems, including:
    • Increased blood pressure and heart rate
    • Sudden death in people with heart problems
    • Sudden death, stroke, and heart attack in adults
  • Mood problems, including
    • Hallucinations (seeing things or hearing voices that aren’t real)
    • Delusions (believing things that aren’t true)
    • Hostile or aggressive behavior
  • Suicidal thoughts and behaviors in children and adolescents with ADHD (boxed warning)

If you’re experiencing suicidal or self-harming thoughts and require immediate assistance, contact a crisis hotline, such as 911, 988 suicide & crisis lifeline (toll-free), or Samaritans (116-123 or via chat).

If you are experiencing serious side effects from taking Strattera, talk with your provider right away. If the side effects are life-threatening or you think it’s a medical emergency, call 911 or your local emergency number.

"Strattera can sometimes worsen anxiety, irritability, or mood in certain people. It’s important to monitor for side effects closely when starting treatment or adjusting the dose of Strattera. Report any side effects to your healthcare provider."
Christina Bookwalter, PharmD
Medical writer and reviewer at MEDvidi

Strattera Drug Interactions

Strattera may interact with certain medications, producing unwanted side effects. The following lists show medications that can interact with Strattera. Note that this list doesn’t include all possible interactions.

Medications that can interact with Strattera include[1]  :[6]

  • Monoamine oxidase inhibitors (MAOIs), including Emsam (selegiline)
  • Medications that affect blood pressure
  • Albuterol containing medications like ProAir HFA
  • Medications that affect Strattera breakdown in the body, including Paxil (paroxetine)

Before starting Strattera, tell your healthcare provider about all the medications you are taking. These include prescription medications, over-the-counter medications, supplements, and recreational substances. They can determine whether Strattera interacts with your current medications.

What Is the Best Time to Take Atomoxetine?

Strattera may be taken any time of day with or without food. Your healthcare provider can help determine the dosing schedule that’s right for you. Note that Strattera may impact sleep[1] with some people reporting difficulty sleeping while others reported drowsiness or tiredness. Side effects can vary from person to person, and each person responds differently to Strattera.

For people who experience drowsiness or tiredness with Strattera treatment, taking the medication at night may be preferred. Nighttime dosing of Strattera may reduce any daytime drowsiness or tiredness you may experience.

Summary

Strattera has been proven effective and is commonly prescribed for the treatment of attention-deficit hyperactivity disorder (ADHD). In some cases, Strattera may also be used off-label to help improve certain ADHD symptoms that people with anxiety also experience, such as difficulty concentrating. 

The medication also comes with several serious risks that should be considered before starting treatment, especially for off-label use. If you are considering medications for treatment of anxiety-related symptoms, consult a licensed healthcare provider at MEDvidi to learn about options that are right for you. 

Frequently Asked Questions (FAQs)

Information and studies on the use of Strattera for anxiety isn’t available. Strattera has only been studied in the treatment of attention-deficit hyperactivity disorder (ADHD). 

Atomoxetine likely doesn’t improve symptoms of depression. Depression was actually a reported side effect[1] in children who used Stattera for the treatment of ADHD. Strattera also carries a boxed warning for the risk of suicidal thoughts and behaviors in children. Adults and children in clinical studies[1] also reported mood-related side effects, including mood swings. Because of this, people with previous or current mood problems should talk with their healthcare provider before starting Strattera.

Information isn’t available on whether Stattera is a safe or effective option for treating social anxiety. Strattera was only approved for the treatment of ADHD[1] at the time this article was written.

Yes. Anxiety was a reported[1] side effect in people who use Stattera (atomoxetine) for treatment of attention-deficit hyperactivity disorder. However, Strattera may help with certain anxiety-related side effects, such as difficulty concentrating.

Strattera can help you feel good by decreasing symptoms of impulsiveness, inability to concentrate, and hyperactivity. Strattera works by increasing certain chemicals in the brain[5] . These chemicals play a key role in controlling behavior and attention. By increasing these brain chemicals, Strattera improves concentration and reduces impulsiveness, allowing you to feel better.

Sources

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6 sources
  1. DailyMed - STRATTERA- atomoxetine hydrochloride capsule. Nih.gov. Published 2024.
    Source link
  2. Centers for Disease Control and Prevention. Data and Statistics on Children’s Mental Health. Children’s Mental Health. Published June 5, 2025.
    Source link
  3. DeGeorge KC, Grover M, Streeter GS. Generalized Anxiety Disorder and Panic Disorder in Adults. American Family Physician. 2022
    Source link
  4. Centers for Disease Control and Prevention. Symptoms of ADHD. Attention-Deficit / Hyperactivity Disorder (ADHD). Published May 15, 2024.
    Source link
  5. medlinePlus. Atomoxetine: MedlinePlus Drug Information. medlineplus.gov. Published May 15, 2022.
    Source link
  6. https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/021411s050lbl.pdf
    Source link
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Dr. Joanne Nguyen
Author
Dr. Joanne Nguyen
PharmD
Christina Bookwalter
Medical Reviewer
Christina Bookwalter
PharmD
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