Content

Depersonalization-Derealization Disorder: Symptoms, Causes, and Treatment

Saya Des Marais
Author:
Saya Des Marais
Medical Writer
Dr. Michael Chichak
Medical Reviewer:
Dr. Michael Chichak
MD

Highlights

  • Depersonalization-derealization disorder (DPDR) is a serious mental health condition that affects up to 2% of the population.
  • Brief episodes of depersonalization and derealization are common, but persistent symptoms that affect daily life may point to DPDR.
  • DPDR treatment often combines talk therapy, lifestyle changes, and sometimes medication. CBT (cognitive-behavioral therapy) and DBT (dialectical behavior therapy) are especially effective approaches.

It’s not uncommon to have brief moments where you feel a bit disconnected from reality. For example, you might be walking somewhere when you notice you made a wrong turn without realizing it. Or you might suddenly feel like time skipped ahead, as if you zoned out for a moment and “missed” part of your experience.

But for some people, this sense of disconnection doesn’t go away. They may frequently feel like they’re detached from themselves or the world around them, to the point where it starts to impact their day-to-day functioning.

If this describes your experience, you may live with depersonalization-derealization disorder. This is a serious mental health condition, but with treatment, you can manage DPDR symptoms and feel more grounded.

Here’s what to know about this relatively rare condition and how to cope with it.

Have a mental health assessment online to get a diagnosis and a personalized treatment plan.

What Is Depersonalization-Derealization Disorder (DPDR)?

Depersonalization-derealization disorder (DPDR) is a mental health condition characterized by persistent feelings of detachment from yourself or your surroundings. Typically, you feel that you’re outside your body or that the environment around you isn’t real. It’s listed as a type of dissociative disorder in the Diagnostic Statistical Manual of Mental Disorders (DSM).

Unlike individuals with psychotic disorders, people with DPDR have insight. This means that they have a better understanding that their symptoms aren’t objectively “real.” But that doesn’t mean that the experience is any less frightening or uncomfortable.

What Is Depersonalization?

Depersonalization is when you feel detached from yourself, your thoughts, or your body. For example, you might feel like you’re observing yourself from outside of your body. It might feel like certain body parts don’t belong to you. You might even be numb to sensations like pain.

"Sometimes, depersonalization is described as an out-of-body experience. While this can happen occasionally within the context of normal, this sensation is much more pervasive in the case of DPDR disorder."
Dr. Michael Chichak
Medical provider at MEDvidi

What Is Derealization?

Derealization can feel similar, but it’s more about feeling disconnected from the world and the environment around you. You might feel like you’re living in a dream and that your surroundings aren’t quite “real.” You might feel like sounds and sights are distorted or that everything around you is “fake.”

Depersonalization

Derealization

Detachment from self

Detachment from surroundings

Feeling like you’re observing yourself

Feeling like the world is dreamlike or unreal

Sense that your body parts don’t belong to you

Distorted sense of space, objects, or time

Numbness to sensations or emotions

Sounds or sights feel altered or “fake”

Feeling like you’re moving automatically, without control

Feeling cut off from familiar places or people

How Common Is Depersonalization Disorder?

Many people experience brief moments of depersonalization or derealization at some point in their lives. In fact, research suggests that up to around 75% of the population[1] will have at least one episode. These short-lived experiences often come during periods of high stress, extreme fatigue, or jet lag, and they can also happen after using certain substances, including alcohol, cannabis, or hallucinogens.

For most people, the feeling passes. But for about 1 to 2%[2] of people worldwide, depersonalization symptoms don’t go away, indicating depersonalization-derealization disorder (DPDR). That means the sense of disconnection is ongoing and severe enough to interfere with everyday life.

Symptoms of Depersonalization-Derealization Disorder

According to the Diagnostic and Statistical Manual of Mental Disorders (DSM), DPDR is diagnosed when:

  • You experience persistent or recurrent depersonalization, derealization, or both.
  • You have intact reality testing (you know your experiences aren’t objectively real).
  • Your symptoms cause significant distress or impairment.
  • Your symptoms aren’t caused by substances, another medical condition, or another mental disorder.

Although they’re not listed in the DSM, some other signs and symptoms that you’re experiencing depersonalization or derealization include: 

  • Feeling cut off from your thoughts, body, or emotions, like you’re not fully “in” yourself.
  • Moving or speaking automatically, almost like you’re on autopilot.
  • Feeling as though the world around you isn’t real or that you’re separated from it.
  • Struggling to put words to your emotions or describe what you’re going through.
  • Feeling numb to physical sensations, like pain or touch.
  • Noticing that objects look distorted — too big, too small, or blurry.
  • Becoming hyper-aware of your surroundings, but in an uncomfortable way.
  • Feeling terrified that you’re “going crazy.”

These depersonalization and derealization symptoms can be:

  • transient, lasting hours to a few days, or
  • chronic, lasting several weeks to months.
"One of the challenges that patients with DPDR disorder face is overcoming stigma. Many times, patients with this condition are told to “simply get over it” or to stop focusing on their symptoms. However, their symptoms are pervasive beyond their control and can lead to social isolation, anxiety, depression and other mental health conditions. It’s important to seek professional help to manage the symptoms."
Dr. Michael Chichak
Medical provider at MEDvidi

It’s relatively common to experience transient depersonalization and derealization symptoms, especially after a traumatic event. But if they don’t go away, or if they’re so severe that they get in the way of functioning, then you may be diagnosed with DPDR.

Only a healthcare provider can diagnose depersonalization-derealization disorder. Contact us if you have any disturbing symptoms.

Causes and Risk Factors

Like most other mental health conditions, there is no singular cause of DPDR. But research has found that there are certain factors that can raise your risk for it[2] .

One of the biggest triggers of DPDR is trauma. People with a history of trauma, especially during childhood, are more likely to develop DPDR symptoms. It’s possible that dissociative symptoms, like depersonalization and derealization, may be the brain’s way of protecting itself[3] against painful memories through emotional blunting.

Examples of traumatic events that can become causes of depersonalization-derealization disorder include:

  • Abuse or neglect.
  • Witnessing domestic violence.
  • Experiencing a sudden loss of a loved one.
  • Being a victim of physical or sexual assault.

Interestingly, emotional neglect, rather than physical abuse, may be more highly linked with these types of symptoms[4] .

Many people who go through a traumatic event may experience temporary symptoms of depersonalization or derealization without developing the full disorder.

Other triggers of derealization symptoms include:

  • Severe emotional stress.
  • History of anxiety disorders.
  • Interpersonal relationship difficulties.
  • Certain substances, especially cocaine, amphetamines, ecstasy, and cannabis.

Studies have found that DPDR also has neurobiological underpinnings[5] . Brain imaging studies show that the prefrontal cortex (involved in thinking and control) can become overactive, which dampens activity in the limbic system, the part of the brain that processes emotions. This may explain why many people with DPDR feel emotionally numb or disconnected. Disruptions in brain areas linked to body awareness and large-scale networks involved in self-reflection may also play a role.

How Is DPDR Diagnosed?

There’s no single test that can diagnose DPDR. Healthcare professionals may use a combination of different methods, including:

  • A clinical interview to understand your symptoms and history.
  • Questionnaires or assessment tools for dissociation.
  • A physical exam or lab tests to rule out neurological conditions.
  • A medication or substance use history to rule out drug-related causes.

Unfortunately, research shows that getting a correct diagnosis for DPDR can take between 7 and 12 years[1] because it’s still so misunderstood even within the medical community. It’s critical to speak with a licensed mental health provider about your symptoms rather than a general practitioner.

DPDR also co-occurs with many other mental health conditions, including post-traumatic stress disorder, anxiety, depression, and more. So it’s essential to find a provider who can untangle all of your symptoms and make the correct diagnoses.

Before diagnosing depersonalization-derealization disorder, the provider must rule out all conditions (such as anxiety, depression, post-traumatic stress disorder, seizure disorders, schizophrenia, and borderline personality disorder). These conditions also often come with feelings of depersonalization and derealization, so if your symptoms are caused by any of these, it’s important to receive an accurate diagnosis.

Depersonalization-Derealization Disorder Treatment

Treating DPDR requires a multifaceted approach. This is a complex condition, and the best treatment is typically a combination of therapy, medication, and lifestyle changes.

Psychotherapy

Psychotherapy is considered the most effective way to treat DPDR. Two approaches are most often used[2] : cognitive-behavioral therapy (CBT) and dialectical behavior therapy (DBT).

Many people with DPDR become stuck in cycles of rumination — focusing on whether they’re “real,” worrying about their sense of self, or checking how they feel over and over. CBT can give you tools to step out of these loops and reduce the anxiety that keeps the symptoms alive. It also helps you notice and challenge the thought patterns that make symptoms worse. You can focus on behavioral changes, like re-engaging in daily activities so that your life doesn’t revolve around your condition.

DBT was originally developed for people with intense emotions and trauma backgrounds, which is why it can be helpful for DPDR. DBT skills can give you concrete ways to ground yourself, regulate overwhelming emotions, and tolerate distress without shutting down.

Medications

Some research[6] has found that DPDR doesn’t respond as well to psychiatric medications as other mental health conditions. But medication can still be part of a comprehensive treatment plan for depersonalization. It can be especially helpful if you deal with a co-occurring mental health condition like anxiety.

Antidepressants, including SSRIs and SNRIs, are usually the medications that are used for DPDR[2] . In some cases, low doses of anti-anxiety medications and anti-psychotic medications can be helpful; a healthcare professional will provide personalized recommendations based on your situation.

Lifestyle Modifications

Making lifestyle changes can also go a long way in helping you manage the symptoms of DPDR. Physical exercise has been shown to decrease anxiety[7] and may help you feel more connected to your body. Getting enough restful sleep is also important, because being sleep-deprived could make you feel even more disconnected.

Grounding and Immediate Coping Strategies

Grounding techniques can also be especially helpful right during the episodes to help ease them. These involve:

  • Using your five senses to re-anchor yourself in the present moment. For example, holding an ice cube can remind you of your body’s physical presence when you feel detached. Physical activity, like walking briskly or engaging in other kinds of exercise, can be helpful. You may also try keeping sensory anchors, such as things with a strong smell you like or objects with unusual textures.
  • A 5-4-3-2-1 technique, which means you should name 5 things you can see at the moment, 4 things you can touch, 3 sounds, 2 smells, and 1 taste. Focus on each of these to feel more present.
  • Focused breathing, which can range from an overall deeper awareness of your breath to box breathing[8] and 4-4-6 breathing.

Prognosis and Living With DPDR

DPDR is a chronic condition, which means there’s no cure for it. But that doesn’t mean that you need to live with severe symptoms forever. Many people are able to manage their symptoms to the point where they can function well in daily life.

The prognosis of DPDR varies for each person. When left untreated, it can last for years and get worse over time. But research shows[2] that with consistent treatment, many people with DPDR are able to recover. The prognosis is better when treatment is received early on, and when co-occurring mental health conditions (like anxiety) are also addressed.

When to Seek Help

Getting treatment early on is linked to a better prognosis for DPDR. Even though some fleeting moments of depersonalization and derealization symptoms are normal, it can still be helpful to see a mental health provider. It’s especially important to get help if these symptoms have come on after a traumatic experience, or if they’re severe enough to be getting in the way of your daily life.

It’s never too early to seek support. You don’t need to wait until symptoms feel unbearable. The earlier you get help, the better the outcome.

Conclusion

Depersonalization-derealization disorder is a dissociative condition marked by ongoing feelings of detachment from yourself or your environment. Trauma, stress, and certain substances are common triggers, and symptoms can feel overwhelming — but they aren’t a sign that you’re “crazy.”

If these symptoms are part of your daily life, reaching out to a mental health professional can make a difference. Treatment can help you feel more present, more grounded, and more connected again.

Frequently Asked Questions

There aren’t official “stages” of DPDR, but people often describe symptoms in phases — from brief episodes of disconnection, to recurring symptoms, to chronic detachment, and, in some cases, long-term impairment.
Someone may have depersonalization if they frequently describe feeling outside their body, emotionally numb, or disconnected from their thoughts and actions, while still knowing these experiences aren’t objectively real.
Conditions like anxiety, depression, PTSD, seizure disorders, and substance use can all cause symptoms that feel similar to DPDR.
No — derealization and psychosis are different. In DPDR, you keep insight and know your experiences aren’t real, whereas in psychosis, reality testing is impaired
DPDR doesn’t progress into schizophrenia, though the two can sometimes be confused. A key difference is that DPDR comes with intact reality testing.
Yes, brief episodes of derealization are common, especially when you’re stressed, exhausted, or sleep deprived.
It varies: episodes may last a few minutes or hours, or in DPDR, symptoms can last for weeks, months, or even longer
For many people, derealization is temporary. With treatment, even chronic DPDR symptoms can improve and become much more manageable.

DPDR most often begins in adolescence or early adulthood (usually before the age of 25[2] ), with onset after age 40 being very rare.

Sources

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8 sources
  1. Hunter EC, Sierra M, David AS. The epidemiology of depersonalisation and derealisation. A systematic review. Soc Psychiatry Psychiatr Epidemiol. 2004 Jan;39(1):9-18. doi: 10.1007/s00127-004-0701-4. PMID: 15022041.
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  2. Wilkhoo HS, Islam AW, Reji F, Sanghvi L, Potdar R, Solanki S. Depersonalization-Derealization Disorder: Etiological Mechanism, Diagnosis and Management. Discoveries (Craiova). 2024 Jun 30;12(2):e190. doi: 10.15190/d.2024.09. PMID: 40093848; PMCID: PMC11910194.
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  3. Bob P. Pain, dissociation and subliminal self-representations. Conscious Cogn. 2008 Mar;17(1):355-69. doi: 10.1016/j.concog.2007.12.001. Epub 2008 Jan 22. PMID: 18207424.
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  4. Brunner R, Parzer P, Schuld V, Resch F. Dissociative symptomatology and traumatogenic factors in adolescent psychiatric patients. J Nerv Ment Dis. 2000 Feb;188(2):71-7. doi: 10.1097/00005053-200002000-00002. PMID: 10695834.
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  5. Murphy RJ. Depersonalization/Derealization Disorder and Neural Correlates of Trauma-related Pathology: A Critical Review. Innov Clin Neurosci. 2023;20(1–3):53–59.
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  6. Murphy RJ. Depersonalization/Derealization Disorder and Neural Correlates of Trauma-related Pathology: A Critical Review. Innov Clin Neurosci. 2023 Jan-Mar;20(1-3):53-59. PMID: 37122581; PMCID: PMC10132272.
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  7. Fang Z, Qian Y, Sun S, et al. Research progress on the mechanism of exercise against anxiety disorder. Sports Medicine and Health Science. Published online September 23, 2025.
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  8. WebMD Editorial Contributors. What Is Box Breathing? WebMD. Published April 8, 2021.
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Saya Des Marais
Author:
Saya Des Marais
Medical Writer
Dr. Michael Chichak
Medical Reviewer:
Dr. Michael Chichak
MD
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