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Is Trintellix Good for Depression Treatment?

Trintellix for depression treatment

Is Trintellix Good for Depression Treatment?

Written by:

Rabia Khaliq

MSc in Applied Psychology

Umar Javed



The medications listed on this website are provided for informational purposes only. Their inclusion does not guarantee that they will be prescribed to any individual, as treatment decisions are ultimately at the discretion of healthcare providers. This list is not exhaustive, and healthcare providers may prescribe other medications, including non-stimulant options, based on the patient’s unique health circumstances and needs.

The drug vortioxetine is used to treat the major depressive disorder (MDD) and is marketed under the brand names Trintellix and Brintellix, among others. It is typically advised for adult patients. The medication has a distinct mechanism of action and does not belong to any antidepressant classes. Selective serotonin inhibitors (SSRIs), atypical antidepressants, and others are all sometimes used to describe this novel multimodal medication.

The Food and Drug Administration (FDA) authorized this medication for major depressive disorder (MDD). Read the article below to learn more about Trintellix’s efficacy for this disorder.

MDD is treatable. Get online mental health assessment from an expert if depression is affecting your life.

Is Trintellix Good for Major Depression?

Trintellix is among the most effective medications for depression in adults. According to clinical studies [1*] , Trintellix is superior to a placebo at reducing the symptoms of MDD. Its users had a 50% reduction in symptoms on average.

Furthermore, a third of those who took it reported total or almost complete symptom improvement. Children are not permitted to use Trintellix: it comes with a boxed warning regarding using medication on depressed children and teenagers as it can increase suicide risk in this age group.

In addition, Trintellix for bipolar depression isn’t an option because it is not a mood stabilizer, and it can cause activation of manic episodes in patients. Therefore, patients should be screened for bipolar disorder before using Trintellex.

Other Trintellix Uses

In addition to treating depression, Trintellix may be used off-label for different conditions, including the following:

  • Generalized anxiety disorder(GAD)
  • Obsessive-compulsive Disorder (OCD)

How Does Trintellix Work?

When some brain chemicals are out of balance, major depressive disorder (MDD) may develop. These chemicals, known as neurotransmitters, function at particular receptors to convey messages from one brain cell to another.

Trintellix is assumed to function, though its exact mechanism of action is yet unknown, by inhibiting the reuptake of a neurotransmitter in the brain called serotonin. Some of the receptors for this brain chemical are also affected by it. It works as an agonist at 5-HT1A receptors, a partial agonist at 5-HT1B receptors, and blocks 5-HT3, 5-HT1D, and 5-HT7 receptors making its functioning challenging to categorize.

Visit a doctor to go over a thorough symptoms check and receive an online depression diagnosis.

Trintellix Dosage

The exact dosage of Trintellix is prescribed by the doctor depending on the nature and severity of the patient’s ailment, any coexisting illnesses, and any other medications they may be taking. The usual beginning Trintellix dosage for depression is 10 milligrams (mg) once daily. Then, this dosage can be raised to 20 mg once daily. Take the missed dose right away if you miss it, but skip it if the next dose is soon due. You shouldn’t take two doses at once to compensate for the lost time.

Trintellix Side Effects

Despite the fact that Trintellix is an effective drug, its potential adverse effects mean that not everyone should use it. The most frequent side effects of Trintellix include:

  • Nausea
  • Diarrhea
  • Dizziness
  • Sleep problems
  • Abnormal dreams
  • Itchy skin
  • Flatulence (gas)
  • Constipation

Trintellix doesn’t seem to have a significant impact on weight. However, this medication shouldn’t be abruptly stopped because it affects serotonin in the brain. Although it is not addictive, withdrawal symptoms should be avoided by gradually lowering the dose over weeks.

Discuss the side effects of medications & how to overcome them with an expert.

Trintellix dosage for depression

FAQs About Trintellix

1. What medications are contraindicated with Trintellix?

This medication may interact negatively (and even fatally) with MAO inhibitors. Therefore, while using this drug, avoid using any MAO inhibitors.

2. Is Trintellix suitable for anxiety disorders?

Off-label use of Trintellix for the treatment of anxiety disorders occurs occasionally. However, the full effects of anxiety may not manifest for up to 4 weeks. Verify the dangers and advantages of this anxiety medication with your doctor.

3. Is Trintellix safe for major depressive disorder treatment?

Trintellix is recommended as an effective MDD treatment, even though it may lead to a few side effects. Serious adverse reactions to this drug include serotonin syndrome.

4. Is alcohol safe to consume when taking Trintellix?

Medical authorities strongly advise against using Trintellix and consuming alcohol simultaneously. Both impact the central nervous system, which results in sedation, drowsiness, and impairment.

5. Is Trintellix an addictive substance?

Trintellix is not a prohibited/controlled substance. Controlled substances have a legal medical use, but they can also be abused or lead to physical or psychological dependence.

Final Words

The medication Trintellix is branded. It includes the active ingredient vortioxetine. There isn’t a generic version of Trintellix available right now, and it is awaiting final FDA approval.

Even though this medicine is a safe alternative for treating MDD, remember that every person’s body reacts to drugs differently. Based on the experiences of others, you cannot accurately anticipate how your body will respond to treatment. Contact MEDvidi doctors to get an individually developed treatment plan based on your symptoms, diagnosis, and health history.


+1 sources
  1. A meta-analysis of randomized, placebo-controlled trials of vortioxetine for the treatment of major depressive disorder in adults. (2016)
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Written by:

Rabia Khaliq

MSc in Applied Psychology

Umar Javed


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Evidence Based

This article is based on scientific evidence, written by experts and fact checked by experts.

Our team of experts strive to be objective, unbiased, honest and to present both sides of the argument.

This article contains scientific references. The numbers
in the parentheses (1, 2, 3) are clickable links to peer-reviewed scientific papers.