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Signs Your Antidepressant Has Stopped Working

Antidepressants lose effectiveness
Written by:

Umar Javed



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The medications listed on this website are provided for informational purposes only. Their inclusion does not guarantee that they will be prescribed to any individual, as treatment decisions are ultimately at the discretion of healthcare providers. This list is not exhaustive, and healthcare providers may prescribe other medications, including non-stimulant options, based on the patient’s unique health circumstances and needs. Read more

When you start taking antidepressants or discuss it with a healthcare professional, you may realize this path is not straightforward. First, the effectiveness of the same antidepressant may vary for different people. Second, its effects may not be noticeable for several weeks even if the medication suits you well. Finally, the medicine may stop being as beneficial over time. So, how to know when you have to wait and when it’s time to switch to another option because the chosen antidepressants are not working? Read on to find it out!

Contact our medical professionals to assess your symptoms and choose a suitable antidepressant medication.

Evaluating Antidepressant Effectiveness: Signs to Watch For

You Feel Better Right Away

It takes up to a few weeks for antidepressants to reach a stable concentration in your body, so it’s not common for them to start working right away. If you experience an immediate boost in your mood, it might be a sign of a placebo effect rather than the medication’s therapeutic action. However, note that the impact of antidepressants is seen quicker in those with severe depression, so it may be the cause of rapid onset of action in some cases.

You Feel a Sudden Surge of Energy — Along With the Blues

A sudden energy boost and restlessness can be a sign of antidepressant-induced mania or hypomania. It happens in about 16% of patients with major depressive disorder [1*] . You might find that your mood has lifted to some extent, but you still don’t feel like your true self. This could be a sign that the antidepressant is only partially effective.

If you experience mood swings, rapid fluctuations between extreme highs and lows, it could indicate that the antidepressant is not effectively stabilizing your mood. It may also mean that you have an underlying condition such as bipolar disorder. It’s essential to reach out to your clinician and discuss this response to medication.

You Experience no Relief After a Few Months or Depression Gets Deeper

If you don’t see positive changes in 4-6 weeks [2*] or your symptoms become worse, it is one of the most obvious signs that your antidepressant isn’t working. If your clinician recommends changing the dosage or adjusting your treatment but you still see no improvement after several months, it might be time to reevaluate your treatment plan again.

When antidepressant medication shows effects

You’re Experiencing Severe Side Effects

According to a survey, 61% of people taking antidepressants experience several unpleasant side effects. The most common ones include emotional numbness, drowsiness, sexual issues, and feeling detached. These effects may fade away during the first weeks of treatment, but if you have severe adverse reactions, consult your clinician.

Suicidal thoughts may also occur, and some antidepressants have a black box warning about that. It’s important to monitor such thoughts and remember that it’s the medication’s effect, not your own wish.

What Causes Depression Medications to Stop Working?

If you notice your antidepressant is no longer working, there may be several reasons. Some of them are discussed below.

You Skipped a Dose or Several

Missing doses can lead to a decline in the medication’s effectiveness. It’s essential to take antidepressants consistently, as prescribed by your healthcare provider.

You Started a New Medication

Starting a new medicine, such as specific painkillers (non-steroidal anti-inflammatory drugs), theophylline for asthma treatment, or some others can impact the effectiveness of your antidepressant. Remember to discuss possible interactions with a healthcare professional when receiving a prescription and inform them about any new medications or herbal supplements you plan to take.

You’re Using Substances

Alcohol, recreational drugs, and even certain prescription medications can affect the action of your antidepressant. Avoid alcohol and other substances during the course of treatment since they can interfere with the medication’s desired effects.

Your Medication Was Stored Wrong

Improper storage, such as exposure to heat or moisture, can lead to a decrease in the medication’s potency. Keep your medication in a cool dry place to make sure it won’t lose its properties.

You Have Another Medical Condition

Some medical conditions can affect the way your body metabolizes antidepressants or responds to them. These include kidney and liver problems, endocrine issues, respiratory disorders, and others. If you have any changes in your health, consult with your prescriber to learn more about potential changes in the effectiveness of your antidepressant.

You’re Pregnant

Pregnancy can alter the way your body processes medication, potentially affecting the effectiveness of your antidepressant. Сonsult with your medical provider to determine if there is a need to tailor your treatment.

You’re Under More Stress

Antidepressants are not magic pills—you have to follow a comprehensive treatment plan to overcome depression. So, if you are going through significant life changes or stressful events, your symptoms can become more challenging to manage, even with medication.

Self-help techniques for depression treatment

You Have Bipolar Disorder, Not Depression

According to some studies, up to 40% of people with bipolar disorder [3*] are diagnosed with major depressive disorder. This condition requires different treatment, so antidepressants will appear ineffective

You’ve Built Up a Tolerance

Over time, your body may become tolerant to the effects of your antidepressant. It means the body adapts to the medicine, so its effects become less evident. However, tolerance is more common in long-term treatment of a few years.

You’re Having Delayed Effects

Antidepressants may take several weeks to work, so the lack of positive changes in your symptoms does not necessarily show the ineffectiveness of the medication. It’s important to not stop antidepressants abruptly but consult a clinician and follow their instructions.

Get ongoing care at MEDvidi: discuss any concerns with your online clinician and receive personalized recommendations.

Three Things to Do When Your Antidepressant Stops Working

Adhere to Your Treatment Plan

Sudden discontinuation of antidepressants may cause withdrawal symptoms. This is because even though you may not notice significant effects at the very beginning of treatment, the medication already influences your body. Moreover, it may take a few more days or weeks to see improvement. It’s crucial to consult with your medical provider before making any changes to your medication regimen and stick to their recommendations.

Talk With a Healthcare Professional

A medical specialist can help assess your current treatment plan and recommend adjustments or alternative options. They may recommend switching to another medicine, using antidepressants along with antipsychotic medication [4*] to improve effectiveness, or incorporating other strategies for managing depression.

Practice Self-care

While medication is an essential part of depression treatment, self-care still plays a significant role in maintaining mental health. A healthy lifestyle, including a nutritious diet, sufficient sleep, regular exercise, and smoking cessation proved to significantly decrease [5*] the risks for depression relapse. It is also helpful to reduce screen time [6*] to better manage the symptoms of depression and also support the impact of medication.

In Conclusion

Recognizing when your antidepressant has stopped working or whether it hasn’t started working in the first place is crucial. The signs can vary from the feeling of immediate improvement to severe mood swings. So, it’s also important to understand potential causes and keep in touch with your clinician. Remember to prioritize a healthy lifestyle too since it has a significant impact on the overall effectiveness of depression treatment.


Abruptly stopping antidepressant medication can lead to withdrawal symptoms and may not be in your best interest. Taking a break from your antidepressant should only be considered under the guidance of a medical professional and if it’s deemed appropriate for your specific situation.
Only a healthcare professional can tell when is the right time to stop antidepressants. This decision typically depends on the improvement in your symptoms and your overall well-being. Usually, patients should take antidepressants for at least six months after achieving stable results, but it’s important to receive personalized recommendations.

Taking antidepressants for an extended period is common for chronic or recurring depression. Under proper medical supervision, it’s possible to maintain positive effects. However, some studies state that taking antidepressants for more than five or ten years increases the risk of cardiovascular problems and diabetes.

People without depression may not experience the intended therapeutic effects of the medication but they may still be susceptible to side effects. It’s crucial to use these medications only when prescribed for a specific condition.
Yes, antidepressants can stop working over time for some individuals. This can occur due to tolerance, changes in metabolism, or drug interactions, among other factors. Regular monitoring by a healthcare professional can help monitor effectiveness and adjust treatment when needed.
Not all antidepressants lose effectiveness over time. Some individuals may find that their medication continues to work well for an extended period. Keep in touch with your clinician and monitor your dynamics to make adjustments when effectiveness seems to decrease.
Changing antidepressants must be discussed with a healthcare specialist. Reasons can include tolerance, ineffectiveness, and intolerable side effects. A clinician will help you transition to a new medication; changing them on your own poses various health risks.

There are no specific stronger antidepressants. The need for change in your antidepressant regimen must be determined by your clinician based on your symptoms and response to treatment. If your current medication is not working properly, your provider may consider adjusting the dosage, prescribing a different antidepressant, or exploring additional treatment options.


6 sources
  1. Antidepressant-induced hypomania/mania in patients with major depression: Evidence from the BRIDGE-II-MIX study
    Source link
  2. Antidepressants
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  3. The Compelling and Persistent Problem of Bipolar Disorder Disguised as Major Depression Disorder: An Integrative Review
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  4. Use of antipsychotics in the treatment of depressive disorders
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  5. Development, acceptability and efficacy of a standardized healthy lifestyle intervention in recurrent depression
    Source link
  6. Multiple lifestyle factors and depressed mood: a cross-sectional and longitudinal analysis of the UK Biobank (N = 84,860)
    Source link
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Written by:

Umar Javed



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Evidence Based

This article is based on scientific evidence, written by experts and fact checked by experts.

Our team of experts strive to be objective, unbiased, honest and to present both sides of the argument.

This article contains scientific references. The numbers
in the parentheses (1, 2, 3) are clickable links to peer-reviewed scientific papers.